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Department of Cancer Research
Our vision is to impact patients’ life by advancing the fight against cancer. Based on strong scientific track-records, we focus on priority research areas and provide research expertise covering the most common and/or malignant cancer types representing a health burden in Luxembourg. The department also represents a state-of-the-art training ground for next generation cancer researchers and acts as a reference point for cancer research in Luxembourg.
Mission
The main mission of the DoCR is to advance the treatment options of cancer and reduce the cancer burden within the Luxembourg population and beyond. It does so through research excellence in priority areas covering the basic, translational and clinical research landscape to foster personalised medicine programmes. Its activities focus on cancers which are difficult to treat. Its team, composed of multiple Research Groups, has dedicated expertise in cancer immunology, the tumour microenvironment, tumor metabolism and neuro-oncology. They explore the cellular and molecular mechanisms of tumor progression using a wide range of state-of-the-art technologies, including multimodal omics technologies (genomics, metabolomics…), advanced immunoprofiling analysis, as well as ex vivo and in vivo imaging modalities leveraging patient data and innovative patient-derived models for cancer research.
DIRECTOR OF DEPARTMENT
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Meiser
- Cancer Metabolism Group
- Cytoskeleton and Cancer Progression
- DNA Repair and Chemoresistance
- In Vivo Imaging
- Luxembourg Centre of Neuropathology
- Multiomics Data Science
- NORLUX Neuro-Oncology Laboratory
- Neuro-Immunology Group
- Translational Radiomics
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
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VISIT OUR
RESEARCH PORTAL
The LIH Research Portal allows you to search and find information about all active researchers, units, outputs, projects and infrastructures.
Projects & clinical trials
Featured team members
Scientific publications
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A comprehensive guide to study the immunological synapse using imaging flow cytometry – 03/04/2024
Céline Hoffmann and 3 other authors -
Actin remodeling in autophagy-mediated tumor immune escape, mechanistic aspects – 08/12/2023
Andrea Michela Biolato -
CSPG4 CAR-redirected Cytokine Induced Killer lymphocytes (CIK) as effective cellular immunotherapy for HLA class I defective melanoma – 22/11/2023
Dario Sangiolo and 26 other authors -
Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse – 21/09/2023
Clément Thomas and 4 other authors -
Correlative light and electron microscopy to explore the lytic immunological synapse between natural killer cells and cancer cells – 05/06/2023
Felix K Borgmann and 4 other authors -
The Immunological Synapse Part B – 11/07/2023
Clément Thomas and 1 other author -
Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus – 15/05/2023
Clément Thomas and 10 other authors -
Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse – 28/04/2023
Salvatore Valitutti and 3 other authors -
An integrated workflow for phosphopeptide identification in natural killer cells (NK-92MI) and their targets (MDA-MB-231) during immunological synapse formation – 09/02/2023
Gunnar Dittmar and 3 other authors -
The Immunological Synapse Part A – 11/01/2023
Clément Thomas and 1 other author -
Ultrarapid lytic granule release from CTLs activates Ca2+-dependent synaptic resistance pathways in melanoma cells – 01/02/2022
Salvatore Valitutti and 13 other authors -
Tumour Immune Evasion is Promoted by Actin Cytoskeleton-Driven Polarization of Inhibitory Signals to the Immunological Synapse – 09/09/2021
Hannah Wurzer -
How natural killer cells avoid self-destruction when killing their targets – 01/08/2021
Clément Thomas and 2 other authors -
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling – 24/05/2021
Clément Thomas and 11 other authors -
Actin Cytoskeleton in Cancer Progression and Metastasis – Part C – 04/05/2021
Clément Thomas and 1 other author -
Illuminating the signaling enigma of Carvedilol – 01/03/2021
Tobias Benkel and 21 other authors -
The multiple roles of actin-binding proteins at invadopodia – 01/01/2021
Clément Thomas and 4 other authors -
Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies – 09/11/2020
Clément Thomas and 4 other authors -
Actin Cytoskeleton in Cancer Progression and Metastasis – Part B – 12/10/2020
Clément Thomas and 1 other author -
Escape of tumor cells from the NK cell cytotoxic activity – 01/10/2020
Massimo Vitale and 3 other authors -
Actin Cytoskeleton in Cancer Progression and Metastasis – Part A – 25/08/2020
Clément Thomas and 1 other author -
The role of heparan sulfate maturation in cancer – 01/05/2020
Sandrine Gulberti and 2 other authors -
Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasion from cytotoxic lymphocytes – 01/01/2020
Andrea Michela Biolato and 6 other authors -
Final project report, METASTALIM Inhibition of breast cancer metastasis by targeting critical cytoskeletal components of invadopodia – 01/01/2020
Clément Thomas -
Final project report, CRP2, an innovative target to inhibit invadopodia activity and pro-metastatic MMP expression in breast cancer – 07/06/2019
Clément Thomas -
Do tumor cells escape from natural killer cell cytotoxicity by mimicking dendritic cells? – 29/03/2019
Clément Thomas and 3 other authors -
Final project report, A LIM domain protein with multiple roles in breast cancer progression and metastasis – 27/02/2019
Clément Thomas -
Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2 – 01/12/2018
Clément Thomas and 9 other authors -
Actin cytoskeleton remodeling drives breast cancer cell escape from natural killer-mediated cytotoxicity – 01/10/2018
Clément Thomas and 13 other authors -
Role of the actin cytoskeleton in breast cancer cell resistance to natural killer cells – 06/07/2018
Antoun Al Absi -
Reactivation of mutant-EGFR degradation through clathrin inhibition overcomes resistance to EGFR tyrosine kinase inhibitors – 15/06/2018
Ludovic Ménard and 3 other authors -
CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT – 03/04/2018
Bassam Janji and 10 other authors -
Driving cytotoxic natural killer cells into melanoma – 01/01/2018
Bassam Janji and 8 other authors -
Subcellular localization and function of 2LIM proteins in plants and humans – 01/12/2017
Clément Thomas and 2 other authors -
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner – 31/10/2017
Bassam Janji and 15 other authors -
The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer – 22/09/2016
Sylvie Fournel-Gigleux and 13 other authors -
Digital skills for health professionals – 01/06/2016
F. Dalati and 10 other authors -
TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics – 01/04/2016
Markus Geisler and 24 other authors -
CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis – 22/03/2016
Clément Thomas and 8 other authors -
The multifaceted role of autophagy in tumor evasion from immune surveillance – 01/01/2016
Bassam Janji and 12 other authors -
The pH sensibility of actin-bundling LIM proteins is governed by the acidic properties of their C-terminal domain – 12/08/2015
Clément Thomas and 8 other authors -
HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors – 25/06/2015
David G. Fernig and 4 other authors -
Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance – 20/11/2014
Bassam Janji and 9 other authors -
A dynamic interplay between membranes and the cytoskeleton critical for cell development and signaling – 16/07/2014
Clément Thomas and 1 other author -
Correction to Live cell imaging reveals actin-cytoskeleton-induced self-association of the actin-bundling protein WLIM1 [J. Cell Sci. 127, 583-598] – 01/03/2014
Céline Hoffmann and 8 other authors -
Involvement of substance P/neurokinin-1 receptor in the analgesic and anticancer activities of minimally toxic fraction from the traditional Chinese medicine Liu-Shen-Wan in vitro – 01/03/2014
Xiao Jun Li and 4 other authors -
Live cell imaging reveals actin-cytoskeleton-induced self-association of the actin-bundling protein WLIM1 – 01/02/2014
Clément Thomas and 8 other authors -
Human muscle LIM protein dimerizes along the actin cytoskeleton and cross-links actin filaments – 01/01/2014
Clément Thomas and 8 other authors -
A LIM domain protein from tobacco involved in actin-bundling and histone gene transcription – 01/03/2013
Danièle Moes and 11 other authors -
Proteomic profiling of rapid non-genomic and concomitant genomic effects of acute restraint stress on rat thymocytes – 03/04/2012
Claude Muller and 5 other authors -
Arabidopsis actin-depolymerizing factors (ADFs) 1 and 9 display antagonist activities – 23/06/2011
Clément Thomas and 8 other authors -
Arabidopsis LIM proteins – 01/09/2010
Jessica Papuga and 7 other authors -
Mouse natural killer (NK) cells express the nerve growth factor receptor TrkA, which is dynamically regulated – 01/01/2010
Jacques Zimmer and 5 other authors -
Actin bundling in plants – 01/11/2009
Clément Thomas and 6 other authors -
Actin bundling via LIM domains – 01/05/2008
Clément Thomas and 6 other authors -
The LIM domains of WLIM1 define a new class of actin bundling modules – 16/11/2007
Clément Thomas and 8 other authors -
Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer – 22/07/2024
Mariona Pascal and 18 other authors -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 16/07/2024
Alessandro Michelucci and 20 other authors -
AllergoOncology – 01/01/2024
Aurélie Poli and 29 other authors -
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 02/04/2024
Anna Golebiewska and 24 other authors -
Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques – 01/04/2024
Menno PJ de Winther and 20 other authors -
Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy – 22/02/2024
Feng Q Hefeng and 38 other authors -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 09/02/2024
Alessandro Michelucci and 17 other authors -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 12/12/2023
Anna Golebiewska and 21 other authors -
SUSD2-IL-2 receptor interaction hinders antitumoral CD8+ T-cell activity – 01/01/2023
Ilaria Salvato and 2 other authors -
A SPECT-based method for dynamic imaging of the glymphatic system in rats – 21/02/2023
Maiken Nedergaard and 12 other authors -
PARK7/DJ-1 in microglia – 18/04/2023
Alessandro Michelucci and 3 other authors -
Transcriptional and Chromatin Accessibility Profiling of Neural Stem Cells Differentiating into Astrocytes Reveal Dynamic Signatures Affected under Inflammatory Conditions – 21/03/2023
Alessandro Michelucci and 8 other authors -
Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice – 01/01/2022
Aurélie Poli and 16 other authors -
Correction – 29/11/2022
Aaqib Sohail and 20 other authors -
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline – 21/10/2022
Maiken Nedergaard and 9 other authors -
Adenovirus-mediated delivery of the MHC-II Transactivator CIITA gene induces tumor cell killing in immunocompetent glioblastoma organoids – 05/09/2022
Ilaria Salvato and 9 other authors -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 05/09/2022
Yahaya Abubakar Yabo and 8 other authors -
Modeling immunocompetent tumor microenvironment in glioblastoma patient-derived orthotopic xenografts – 05/09/2022
Pilar Maria Moreno Sanchez and 8 other authors -
AllergoOncology – 01/01/2022
Sophia N. Karagiannis and 30 other authors -
Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency – 01/01/2022
Alessandro Michelucci and 13 other authors -
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism – 01/05/2022
Frank Pessler and 20 other authors -
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson’s disease – 29/01/2022
Manuel Buttini and 24 other authors -
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection – 13/01/2022
Frank Pessler and 20 other authors -
Special issue “microglia heterogeneity and its relevance for translational research” – 16/11/2021
Alessandro Michelucci and 2 other authors -
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation – 09/11/2021
Gerhard Krönke and 25 other authors -
Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice – 01/01/2021
Manuel Buttini and 17 other authors -
Allergic airway inflammation impacts tumor take and delays experimental glioblastoma progression – 01/09/2021
Aurélie Poli and 13 other authors - Tumour-associated microglia/macrophage (TAM) heterogeneity in Glioblastoma – 22/06/2021
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Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors – 18/06/2021
Anaïs Oudin and 16 other authors -
FAM13A regulates KLRG1 expression and interferon gamma production of natural killer cells – 18/05/2021
Ni Zeng and 14 other authors -
Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus – 12/04/2021
Danielle PerezBercoff and 13 other authors -
NF-kappa B and TNF Affect the Astrocytic Differentiation from Neural Stem Cells – 08/04/2021
Cindy Birck and 5 other authors -
Microglia in Health and Disease – 31/03/2021
Alessandro Michelucci and 3 other authors -
Single-cell transcriptomics and In situ morphological analyses reveal microglia heterogeneity across the nigrostriatal pathway – 29/03/2021
Alessandro Michelucci and 8 other authors -
CpG Adjuvant in Allergen-Specific Immunotherapy – 23/02/2021
Markus Ollert and 3 other authors -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
Simone Niclou and 40 other authors -
Interrogating intratumoral transcriptomic heterogeneity and plasticity as resistance mechanisms in glioblastoma – 01/11/2020
Yahaya Abubakar Yabo and 8 other authors -
Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging – 23/09/2020
Lasse Sinkkonen and 16 other authors -
Revealing and harnessing tumour-associated microglia/macrophage heterogeneity in glioblastoma – 01/02/2020
Alessandro Michelucci and 1 other author -
BCL2L15 (BCL2-like 15) – 01/01/2020
Pinelopi I. Artemaki and 2 other authors -
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment – 01/12/2019
Simone Niclou and 21 other authors -
Allergooncology: Delayed glioblastoma progression in a mouse model of allergic airway inflammation – 01/08/2019
Aurélie Poli and 13 other authors -
Region-specific microglial heterogeneity and its potential relevance for Parkinson’s disease – 01/07/2019
Oihane Uriarte Huarte and 8 other authors -
Transcriptional and epigenetic mechanisms underlying astrocyte identity – 01/03/2019
Alessandro Michelucci and 4 other authors -
Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures – 01/11/2018
Alessandro Michelucci and 11 other authors -
Microglia in health and disease: A unique immune cell population – 01/09/2018
Alessandro Michelucci and 2 other authors -
Single-cell transcriptomic analysis of microglia/macrophages in glioblastoma – 01/09/2018
Alessandro Michelucci and 6 other authors -
Microglia in health and disease – 15/08/2018
Alessandro Michelucci and 2 other authors -
Delayed glioblastoma progression by repeated nasal instillations of house dust mite extract in a mouse model – 01/08/2018
Aurélie Poli and 11 other authors -
Human leukocyte antigen class I deficiencies – 01/06/2017
Jacques Zimmer and 2 other authors -
Human CD56bright NK cells – 01/04/2016
Jacques Zimmer and 6 other authors -
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma – 30/09/2014
Cecilie Brekke Rygh and 11 other authors -
Combining NK cells and mAb9.2.27 to combat NG2-dependent and anti-inflammatory signals in glioblastoma – 01/01/2014
Martha Chekenya Enger and 5 other authors -
TAP deficiency is also a cause of bronchiectasis – 01/05/2013
Jacques Zimmer and 4 other authors -
Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level – 01/01/2013
Martha Chekenya Enger and 7 other authors -
Mouse Lung and Spleen Natural Killer Cells Have Phenotypic and Functional Differences, in Part Influenced by Macrophages – 05/12/2012
Tatiana Michel and 7 other authors -
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma – 01/10/2011
Martha Chekenya Enger and 21 other authors -
Increased Th2 cytokine secretion, eosinophilic airway inflammation, and airway hyperresponsiveness in neurturin-deficient mice – 01/06/2011
Tatiana Michel and 7 other authors -
Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescence-activated cell sorting – 01/11/2010
Aurélie Poli and 6 other authors -
NK cells and allergy – 01/01/2010
Tatiana Michel and 4 other authors -
CD56bright natural killer (NK) cells – 01/04/2009
Jacques Zimmer and 5 other authors -
A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions – 01/09/2008
Simone Niclou and 10 other authors -
Control of NK cell functions by CD4+CD25+ regulatory T cells – 01/01/2007
Jacques Zimmer and 6 other authors -
Reduced cytokine-mediated up-regulation of HLA-DR in TAP-deficient fibroblasts – 15/11/2006
Jacques Zimmer and 5 other authors -
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy – 01/01/2024
Bassam Janji and 22 other authors -
Identification of the role of HIF-1α-dependent hypoxia in the regulation of ACKR2 (Atypical Chemokine Receptor 2) expression in cancer – 26/06/2024
Alice Benoit -
Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34 – 01/01/2024
Bassam Janji and 2 other authors -
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden – 28/11/2023
Salem Chouaib and 12 other authors -
CyPep-1 reprograms the tumor microenvironment and enhances the efficacy of immune checkpoint inhibitors – 01/10/2023
Bassam Janji and 7 other authors -
Lighting Up the Fire in the Microenvironment of Cold Tumors – 05/07/2023
Bassam Janji and 4 other authors -
Nanoluciferase-based complementation assays to monitor activation, modulation and signaling of receptor tyrosine kinases (RTKs) – 24/12/2022
Andy Chevigne and 7 other authors -
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo – 23/12/2022
Teresa Ramos and 20 other authors -
Dual blockage of both PD-L1 and CD47 enhances the therapeutic effect of oxaliplatin and FOLFOX in CT-26 mice tumor model – 11/02/2023
Seyed Amir Jalali and 8 other authors -
Basic Concepts of Radiation Biology – 01/01/2023
Ans Baeyens and 30 other authors -
Clinical Radiobiology for Radiation Oncology – 01/01/2023
Peter Sminia and 26 other authors -
Individual Radiation Sensitivity and Biomarkers – 01/01/2023
Elizabeth A. Ainsbury and 19 other authors -
Radiobiology of Accidental, Public, and Occupational Exposures – 01/01/2023
Ruth Wilkins and 17 other authors -
Space Radiobiology – 01/01/2023
Yehoshua Socol and 24 other authors -
A role for EMT in CD73 regulation in breast cancer – 30/11/2022
Bassam Janji and 2 other authors -
The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation – 15/11/2022
Bassam Janji and 8 other authors -
Hypoxia features as potential indicators in prognosis, immunotherapy and drug screening in hepatocellular carcinoma patients – 12/10/2022
Ruize Gao -
Improving neuroblastoma therapy by targeting intratumoral hypoxia and immune checkpoint PD-L1 – 23/09/2022
Delphine Sauvage -
SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC – 09/09/2022
Bassam Janji and 13 other authors -
The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
Bassam Janji and 7 other authors -
Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments – 26/08/2022
Seyed Amir Jalali and 10 other authors -
Radiation dose and schedule influence the abscopal effect in a bilateral murine CT26 tumor model – 10/04/2022
Seyed Amir Jalali and 8 other authors -
The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy – 20/06/2022
Bassam Janji and 1 other author -
VPS34 inhibitor SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist – 15/06/2022
Yasmin Yu and 11 other authors -
The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B – 01/06/2022
Andy Chevigne and 10 other authors -
CMTM6 and CMTM7 – 01/01/2022
Bassam Janji and 4 other authors -
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis – 16/05/2022
Johannes Meiser and 18 other authors -
Editor’s Note – 15/04/2022
Yosra Messai and 21 other authors -
Carbonic Anhydrase IX – 09/03/2022
Najla Santos Pacheco de Campos and 7 other authors -
Nanoluciferase-based methods to monitor activation, modulation and trafficking of atypical chemokine receptors – 18/04/2022
Martyna Szpakowska and 9 other authors -
Impact of epithelial to mesenchymal transition on the regulation of anti-tumour immune response in breast cancer – 16/11/2021
Malina Xiao -
Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model – 01/10/2021
Laura Ochoa-Callejero and 23 other authors -
“Suffocating” tumors by blocking adaptation to hypoxia – 07/09/2021
Bassam Janji and 1 other author -
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy – 01/01/2021
Bassam Janji and 11 other authors -
Mitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer Metastasis – 27/05/2021
Johannes Meiser and 16 other authors -
Epithelial to mesenchymal transition regulates surface pd-l1 via cmtm6 and cmtm7 induction in breast cancer – 09/03/2021
Malina Xiao and 10 other authors -
Cxcl10 is an agonist of the cc family chemokine scavenger receptor ackr2/d6 – 02/03/2021
Martyna Szpakowska and 11 other authors -
Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies – 25/02/2021
Bassam Janji and 7 other authors -
CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis – 01/01/2021
Gwendalyn J. Randolph and 11 other authors -
Selection of tumor-resistant variants following sustained natural killer cell-mediated immune stress – 01/02/2021
Salem Chouaib and 8 other authors -
Specific ACKR2 modulators for use in therapy – 21/01/2021
Bassam Janji and 5 other authors -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) – 01/01/2021
Daniel J. Klionsky and 2928 other authors -
Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34 – 01/11/2020
Bassam Janji and 5 other authors -
Impact du ciblage du domaine de liaison de HIF-1α avec HIF-1b sur le paysage immunitaire du mélanome – 09/10/2020
Audrey Lequeux -
CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems – 05/10/2020
Bernhard Moser and 11 other authors -
The ‘Holy Grail’ in Immuno-Oncology – 01/10/2020
Andreas Schläpfer and 4 other authors -
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway – 02/08/2020
Elisabeth Letellier and 19 other authors -
Checkpoint Inhibitors and Engineered Cells – 29/06/2020
Massimo Giuliani and 1 other author -
The emerging impact of autophagy on the antitumor immune response – 15/05/2020
Meriem Hasmim and 6 other authors -
Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21 – 07/04/2020
Natasha A. Moussouras and 7 other authors -
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy – 01/04/2020
Bassam Janji and 12 other authors -
Assessing autophagy in archived tissue or how to capture autophagic flux from a tissue snapshot – 01/03/2020
Magali Humbert and 17 other authors -
Firing up the cold tumors by targeting Vps34 – 01/01/2020
Bassam Janji and 4 other authors -
The diverse and complex roles of atypical chemokine receptors in cancer – 01/01/2020
Elin Sjöberg and 5 other authors -
Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment – 01/09/2019
Muhammad zaeem NOMAN and 7 other authors -
Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints – 28/08/2019
Bassam Janji and 10 other authors -
The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment – 18/06/2019
Andy Chevigne and 10 other authors -
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide – 01/04/2019
Lars Prestegarden and 19 other authors -
Actin cytoskeleton remodeling drives breast cancer cell escape from natural killer-mediated cytotoxicity – 01/10/2018
Clément Thomas and 13 other authors -
Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer – 28/08/2018
Victoria El Khoury and 13 other authors -
Driving Natural Killer cells toward the melanoma tumor battlefield – 03/08/2018
Bassam Janji and 4 other authors -
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia – 03/08/2018
Marina Wierz and 4 other authors -
Impact of targeting the autophagy related gene Beclin 1 on the immune landscape of melanoma – 09/07/2018
Tsolère Arakelian -
Inhibition of HIF1α-dependent upregulation of phospho-L-Plastin resensitizes multiple myeloma cells to frontline therapy – 01/06/2018
Bassam Janji and 10 other authors -
Targeting autophagy in the tumor microenvironment – 25/04/2018
Bassam Janji and 2 other authors -
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia – 05/04/2018
Marina Wierz and 12 other authors -
CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT – 03/04/2018
Bassam Janji and 10 other authors -
Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield – 03/04/2018
Bassam Janji and 2 other authors -
Driving cytotoxic natural killer cells into melanoma – 01/01/2018
Bassam Janji and 8 other authors -
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner – 31/10/2017
Bassam Janji and 15 other authors -
Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A – 05/09/2017
Simone Niclou and 10 other authors -
The role of autophagy in anti-tumour immune response mediated by Natural Killer cells – 26/06/2017
Takouhie Mgrditchian -
Human CD56dimCD16dimCells As an Individualized Natural Killer Cell Subset – 19/06/2017
Jacques Zimmer and 11 other authors -
Cutting edge – 15/02/2017
Salem Chouaib and 9 other authors -
Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure – 01/02/2017
Salem Chouaib and 8 other authors -
The critical role of hypoxia in tumor-mediated immunosuppression – 01/02/2017
Bassam Janji and 5 other authors -
The immune checkpoint ligand PD-l1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200 – 02/01/2017
Salem Chouaib and 8 other authors -
Activation of NK cells and disruption of PD-L1/PD-1 axis – 01/01/2017
Massimo Giuliani and 2 other authors -
Mesenchymal stromal cells can regulate the immune response in the tumor microenvironment – 01/12/2016
Alessandro Poggi and 1 other author -
Hijacker of the antitumor immune response – 18/11/2016
Bassam Janji and 8 other authors -
Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status – 01/10/2016
Salem Chouaib and 18 other authors -
miR-210 and hypoxic microvesicles – 01/09/2016
Salem Chouaib and 3 other authors -
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer – 02/04/2016
Salem Chouaib and 10 other authors -
CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis – 22/03/2016
Clément Thomas and 8 other authors -
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) – 21/01/2016
Daniel J. Klionsky and 2461 other authors -
Autophagy Activation in the Tumor Microenvironment – 01/01/2016
Bassam Janji and 5 other authors -
Erratum to – 01/01/2016
Daniel J. Klionsky and 2461 other authors -
Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer – 01/01/2016
Victoria El Khoury and 3 other authors -
Role of Autophagy in Tumor Progression and Regression – 01/01/2016
Bassam Janji and 1 other author -
The multifaceted role of autophagy in tumor evasion from immune surveillance – 01/01/2016
Bassam Janji and 12 other authors -
Autophagy regulation of the tumor immunity: An old housekeeper for a new function – 16/12/2015
Tsolère Arakelian and 6 other authors -
miR-181a modulates acute myeloid leukemia susceptibility to natural killer cells – 02/12/2015
Salem Chouaib and 10 other authors -
The selective degradation of synaptic connexin 43 protein by hypoxia-induced autophagy impairs natural killer cell-mediated tumor cell killing – 25/09/2015
Salem Chouaib and 4 other authors -
Tumor-promoting effects of myeloid-derived suppressor cells are potentiated by hypoxia-induced expression of miR-210 – 15/09/2015
Salem Chouaib and 6 other authors -
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts – 27/08/2015
Jérôme Paggetti and 11 other authors -
Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells – 19/06/2015
Nassera Aouali and 8 other authors -
Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression – 23/04/2015
Salem Chouaib and 10 other authors -
Hypoxia – 01/01/2015
Salem Chouaib and 6 other authors -
ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy – 01/12/2014
Salem Chouaib and 21 other authors -
Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance – 20/11/2014
Bassam Janji and 9 other authors -
Autophagy – 01/11/2014
Bassam Janji and 6 other authors -
Hypoxia-induced autophagy in tumor cells: a key target for improving cancer immunotherapy – 14/09/2014
Jérôme Paggetti and 4 other authors -
Bronchial airway gene expression in smokers with lung or head and neck cancer – 01/04/2014
Eric Van Dyck and 15 other authors -
EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction – 01/07/2013
Salem Chouaib and 6 other authors -
Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from t-cell-mediated lysis – 15/04/2013
Salem Chouaib and 16 other authors -
Guidelines for the use and interpretation of assays for monitoring autophagy – 01/04/2012
Daniel J. Klionsky and 1268 other authors -
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression – 15/09/2011
Salem Chouaib and 10 other authors -
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia – 19/04/2011
Etienne Moussay and 10 other authors -
Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response – 01/01/2011
Salem Chouaib and 7 other authors -
Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
Jonathan Turner and 10 other authors -
Corrigendum to ‘Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model’ [Ultrasound in Med & Biol. 49 (2023) 1082-1090, (S0301562922006664), (10.1016/j.ultrasmedbio.2022.12.006)] – 01/01/2024
Yanrong Zhang and 13 other authors -
Immune cell identity behind the Ktrans mapping of mouse glioblastoma – 21/06/2023
Max Wintermark and 13 other authors -
Large-Scale Deep Learning Medical Image Methodology and Applications using Multiple GPUs – 12/10/2023
Ezhilmathi Krishnasamy and 5 other authors -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model – 01/01/2023
Max Wintermark and 13 other authors -
Author Correction – 26/01/2023
Spyridon Bakas and 278 other authors -
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Spyridon Bakas and 278 other authors -
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Wenjing Zhou and 30 other authors -
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Bassam Janji and 7 other authors -
Federated Learning Enables Big Data for Rare Cancer Boundary Detection – 22/04/2022
Spyridon Bakas and 278 other authors -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia after MRgFUS induced BBB Opening in a Mouse Glioblastoma Model – 15/03/2022
Max Wintermark and 13 other authors -
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Daniele Perlo and 6 other authors -
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Hanène Samouda and 5 other authors -
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Frits Thorsen and 5 other authors -
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Katharina Sarnow and 3 other authors -
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Max Wintermark and 13 other authors -
Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors – 18/06/2021
Anaïs Oudin and 16 other authors -
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Simone Niclou and 40 other authors -
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Michal Bartos and 5 other authors -
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Frits Thorsen and 17 other authors -
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Synnøve Nymark Aasen and 17 other authors -
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Hynek Walner and 6 other authors -
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Etienne Moussay and 5 other authors -
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Anne Largeot and 4 other authors -
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Laurent Delva and 16 other authors -
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Iria Fernandez Botana -
Editorial – 08/05/2024
Martin Böttcher and 2 other authors -
Eμ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia – 18/04/2024
Jérôme Paggetti and 4 other authors -
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle – 28/02/2024
Johannes Meiser and 20 other authors -
Minimal information for studies of extracellular vesicles (MISEV2023) – 01/02/2024
Joshua A. Welsh and 49 other authors -
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Giulia Petroni and 4 other authors -
Power out chronic lymphocytic leukemia – 03/08/2023
Jérôme Paggetti and 1 other author -
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Lorenzo Galluzzi and 3 other authors -
Role of AHR and HIF1α transcription factors in normal and chronic lymphocytic leukemia B lymphocytes – 21/12/2023
Susanne Gonder -
Targeting mRNA translation aberrations – 01/01/2023
Etienne Moussay and 3 other authors -
Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia – 03/11/2023
Jérôme Paggetti and 3 other authors -
Interleukin-27 potentiates CD8+ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia – 22/06/2023
Jérôme Paggetti and 16 other authors -
Immunologically relevant effects of radiation therapy on the tumor microenvironment – 18/05/2023
Lorenzo Galluzzi and 4 other authors -
Formate promotes invasion and metastasis in reliance on lipid metabolism – 30/08/2023
Johannes Meiser and 26 other authors -
Type I interferon and cancer – 01/01/2023
Jitka Fucikova and 6 other authors -
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Martina Seiffert and 28 other authors -
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Anne Largeot and 32 other authors -
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Lorenzo Galluzzi and 5 other authors -
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Anne Largeot and 32 other authors -
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Carsten U Niemann and 2 other authors -
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells – 01/01/2023
Johannes Meiser and 33 other authors -
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Pablo Elias Morande and 5 other authors -
PKM2 diverts glycolytic flux in dependence on formate overflow – 23/01/2023
Johannes Meiser and 17 other authors -
Role of AHR, HIF-1α and IL-27 In T-cell-mediated immunity in chronic lymphocytic leukemia – 09/01/2023
Giulia Pagano -
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses – 15/09/2022
Jérôme Paggetti and 16 other authors -
T cell landscape definition by multi-omics identifies Galectin-9 as novel immunotherapy target in chronic lymphocytic leukemia – 16/12/2022
Martina Seiffert and 26 other authors -
Single-Cell Omics Analyses Identify the TIM-3 Ligand Galectin-9 As Novel Immunotherapy Target for Chronic Lymphocytic Leukemia – 15/11/2022
Laura Llaó Cid and 15 other authors -
Small extracellular vesicles – 27/09/2022
Ernesto Gargiulo and 3 other authors -
The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
Bassam Janji and 7 other authors -
Natural killer cells and bone marrow mesenchymal stem cells – 28/07/2022
Jérôme Paggetti and 2 other authors -
Targeting translation by disrupting the newly identified prohibitin-eif4f complex as a novel therapeutic strategy in chronic lymphocytic leukemia – 01/06/2022
Anne Largeot and 9 other authors -
Editor’s Note – 15/04/2022
Yosra Messai and 21 other authors -
PRMT2 : un facteur épigénétique anti-inflammatoire impliqué dans l’agressivité des leucémies aiguës myéloblastiques – 01/03/2022
C. Sauter and 14 other authors -
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Agnieszka Goral and 17 other authors -
Editorial – 03/02/2022
Martina Seiffert and 2 other authors -
Editorial – 17/01/2022
Etienne Moussay and 2 other authors -
Editorial – 15/12/2021
Jérôme Paggetti and 2 other authors -
Impact of small extracellular vesicles on anti-tumor immunity in chronic lymphocytic leukemia in vivo – 17/11/2021
Ernesto Gargiulo -
The tumor microenvironment-dependent transcription factors ahr and hif-1α are dispensable for leukemogenesis in the eµ-tcl1 mouse model of chronic lymphocytic leukemia – 08/09/2021
Susanne Gonder and 7 other authors -
In Vitro Sensitivity to Venetoclax and Microenvironment Protection in Hairy Cell Leukemia – 26/07/2021
Pablo Elias Morande and 14 other authors -
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms – 22/07/2021
Pablo Oppezzo and 19 other authors -
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy – 01/01/2021
Bassam Janji and 11 other authors -
Immunomodulatory effects of different intravenous immunoglobulin preparations in chronic lymphocytic leukemia – 21/06/2021
Mercedes Borge and 8 other authors -
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling – 24/05/2021
Clément Thomas and 11 other authors -
Method for the Analysis of the Tumor Microenvironment by Mass Cytometry – 20/10/2020
Susanne Gonder and 8 other authors -
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Ernesto Gargiulo and 4 other authors -
Characterisation of the tumour microenvironment in chronic lymphocytic leukemia by mass cytometry: implications for immunotherapy – 14/09/2020
Marina Wierz -
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway – 02/08/2020
Elisabeth Letellier and 19 other authors -
Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasion from cytotoxic lymphocytes – 01/01/2020
Andrea Michela Biolato and 6 other authors -
Eomes and IL-10 Regulate Anti-Tumor Activity of T Cells in Chronic Lymphocytic Leukemia – 13/11/2019
Laura Llao Cid and 10 other authors -
Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints – 28/08/2019
Bassam Janji and 10 other authors -
Hematological malignancy-derived small extracellular vesicles and tumor microenvironment – 27/05/2019
Ernesto Gargiulo and 2 other authors -
The B-side of cancer immunity – 13/05/2019
Anne Largeot and 4 other authors -
HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells – 11/04/2019
Carmen Garrido and 18 other authors -
Chronic Lymphocytic Leukaemia-derived exosomes: A potential strategy for immune escape – 01/01/2019
Ernesto Gargiulo -
Chronic Lymphocytic Leukaemia-derived small extracellular vesicles: A potential strategy for immune escape – 01/01/2019
Ernesto Gargiulo -
Purification of leukemia-derived exosomes to study microenvironment modulation – 01/01/2019
Jérôme Paggetti and 5 other authors -
Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis – 01/10/2018
Azim Dehghani Amirabad and 6 other authors -
Driving Natural Killer cells toward the melanoma tumor battlefield – 03/08/2018
Bassam Janji and 4 other authors -
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia – 03/08/2018
Marina Wierz and 4 other authors -
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia – 05/04/2018
Marina Wierz and 12 other authors -
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model – 23/03/2018
Marina Wierz and 7 other authors -
Exosome proteins and RNAas biomarkers of hematologic malignancies development and progression – 01/01/2018
Ernesto Gargiulo -
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner – 31/10/2017
Bassam Janji and 15 other authors -
Tumor-derived exosomes modulate PD-L1 expression in monocytes – 01/01/2017
Martina Seiffert and 20 other authors -
Hijacker of the antitumor immune response – 18/11/2016
Bassam Janji and 8 other authors -
A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells – 01/07/2016
Sandrine Medves and 15 other authors -
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer – 02/04/2016
Salem Chouaib and 10 other authors -
BCR engagement in CLL – 28/01/2016
Jérôme Paggetti and 1 other author -
Assessing cellular and circulating miRNA recovery – 20/01/2016
Victoria El Khoury and 4 other authors -
Autophagy Activation in the Tumor Microenvironment – 01/01/2016
Bassam Janji and 5 other authors -
The multifaceted role of autophagy in tumor evasion from immune surveillance – 01/01/2016
Bassam Janji and 12 other authors -
Autophagy regulation of the tumor immunity: An old housekeeper for a new function – 16/12/2015
Tsolère Arakelian and 6 other authors -
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts – 27/08/2015
Jérôme Paggetti and 11 other authors -
ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy – 01/12/2014
Salem Chouaib and 21 other authors -
Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance – 20/11/2014
Bassam Janji and 9 other authors -
Hypoxia-induced autophagy in tumor cells: a key target for improving cancer immunotherapy – 14/09/2014
Jérôme Paggetti and 4 other authors -
Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia – 01/08/2014
Victoria El Khoury and 7 other authors -
Bronchial airway gene expression in smokers with lung or head and neck cancer – 01/04/2014
Eric Van Dyck and 15 other authors -
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression – 15/09/2011
Salem Chouaib and 10 other authors -
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia – 19/04/2011
Etienne Moussay and 10 other authors -
Peroxisome proliferator-activated receptor γ agonists potentiate the cytotoxic effect of valproic acid in multiple myeloma cells – 01/12/2009
Guy Berchem and 10 other authors -
Digital voice-based biomarker for monitoring respiratory quality of life – 01/10/2024
Vladimir Despotovic and 6 other authors -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 16/07/2024
Alessandro Michelucci and 20 other authors -
consICA – 13/07/2024
Petr Nazarov and 4 other authors -
AllergoOncology – 01/01/2024
Aurélie Poli and 29 other authors -
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Javier Vaquero and 2 other authors -
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 02/04/2024
Anna Golebiewska and 24 other authors -
Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells – 25/03/2024
Madhuri S. Salker and 13 other authors -
Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning – 15/03/2024
Vladimir Despotovic and 8 other authors -
Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
Jonathan Turner and 10 other authors -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 09/02/2024
Alessandro Michelucci and 17 other authors -
Most accurate mutations in SARS-CoV-2 genomes identified in Uzbek patients show novel amino acid changes – 01/01/2024
Ibrokhim Y. Abdurakhmonov and 10 other authors -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 12/12/2023
Anna Golebiewska and 21 other authors -
Inhibition of MIR-146A-5P decreases progression of melanoma brain metastasis via notch pathway dysregulation in astrocytes – 10/11/2023
E. K. Rigg and 19 other authors -
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Alexandros Pailas and 9 other authors -
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Emma Rigg and 19 other authors -
Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study – 29/09/2023
Vladimir Despotovic and 8 other authors -
Integrative omics analysis of IDH1 mutant glioma patients reveals alterations in butyrate metabolism – 08/09/2023
Sabrina Fritah and 9 other authors -
Stability of stochastic dynamic systems of a random structure with Markov switching in the presence of concentration points – 16/08/2023
Petr Nazarov and 3 other authors -
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Anne Largeot and 32 other authors -
Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response – 27/06/2023
Stephanie Kreis and 11 other authors -
Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing – 01/07/2023
Ibrokhim Abdurakhmonov and 9 other authors -
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL – 01/01/2023
Anne Largeot and 32 other authors -
Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas – 06/06/2023
Eric Van Dyck and 4 other authors -
Stability of stochastic dynamic systems of a random structure with Markov switchings in the presence of concentration points – 19/05/2023
Taras Lukashiv and 3 other authors -
Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking – 22/03/2023
Christoph Plass and 19 other authors -
Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice – 01/01/2022
Aurélie Poli and 16 other authors -
Stabilization of Stochastic Dynamical Systems of a Random Structure with Markov Switches and Poisson Perturbations – 01/02/2023
Petr Nazarov and 4 other authors -
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses – 15/09/2022
Jérôme Paggetti and 16 other authors -
Stabilization of stochastic dynamical systems of a random structure with Markov switches and Poisson perturbations – 15/12/2022
Taras Lukashiv and 4 other authors -
Vocal biomarker predicts fatigue in people with COVID-19 – 22/11/2022
Guy Fagherazzi and 7 other authors -
Deciphering Human Glioblastoma Invasion Using a Developmental Mature Rat Brain Organoid Model – 15/11/2022
Wenjing Zhou and 30 other authors -
Discovery and Analytical Validation of a Vocal Biomarker to Monitor Anosmia and Ageusia in Patients with COVID-19 – 07/09/2022
Guy Fagherazzi and 6 other authors -
A voice-based biomarker for monitoring symptom resolution in adults with COVID-19 – 20/10/2022
Guy Fagherazzi and 8 other authors -
Extracellular vesicle derived-MIR-146A increases melanoma brain metastasis progression via notch signalling pathway dysregulation – 05/09/2022
E. K. Rigg and 16 other authors -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 05/09/2022
Yahaya Abubakar Yabo and 8 other authors -
Ten quick tips for biomarker discovery and validation analyses using machine learning – 11/08/2022
Enrico Glaab and 7 other authors -
Long COVID Symptomatology After 12 Months and Its Impact on Quality of Life According to Initial Coronavirus Disease 2019 Disease Severity – 05/08/2022
Guy Fagherazzi and 8 other authors -
Linear system identifiability from single-cell data – 01/07/2022
Jorge Goncalves and 2 other authors -
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Atte Aalto and 7 other authors -
BIODICA – 06/04/2022
Nicolas Captier and 8 other authors -
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Antonio Marchini and 8 other authors -
ORFhunteR – 01/05/2022
Vasily V. Grinev and 4 other authors -
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V. M. Lutkovski and 1 other author -
A DNA Damage Repair Signature in Pediatric High-Grade Gliomas: XRCC1 and PARP1, Key Biomarkers – 01/11/2021
N. Entz-Werle and 6 other authors -
In silico approach for validating and unveiling new applications for prognostic biomarkers of endometrial cancer – 09/10/2021
Eva Coll de la Rubia and 7 other authors -
DECONbench – 02/10/2021
Clémentine Decamps and 50 other authors -
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase – 27/09/2021
Eric Van Dyck and 16 other authors -
Allergic airway inflammation impacts tumor take and delays experimental glioblastoma progression – 01/09/2021
Aurélie Poli and 13 other authors -
Phenotypic heterogeneity and plasticity as resistance mechanisms in glioblastoma – 01/09/2021
Yahaya Abubakar Yabo and 5 other authors -
PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα – 25/06/2021
Achim Leutz and 10 other authors -
A DNA repair and cell cycle gene expression signature in pediatric high‐grade gliomas – 07/05/2021
Natacha Entz‐werlé and 13 other authors -
Integrative approaches for analysis of mRNA and microRNA high-throughput data – 01/01/2021
Petr Nazarov and 1 other author -
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion – 01/12/2020
Simone Niclou and 18 other authors -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
Simone Niclou and 40 other authors -
Systematic Transcriptional Profiling of Responses to STAT1- and STAT3-Activating Cytokines in Different Cancer Types – 06/11/2020
Stephanie Kreis and 9 other authors -
Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz – 01/10/2020
Pavlo Lutsik and 10 other authors -
Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics – 26/08/2020
Mi Yang and 50 other authors -
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway – 02/08/2020
Elisabeth Letellier and 19 other authors -
Deconvolution of “big data” in cancer genomics: from pancancer level to single cells – 09/07/2020
M. Chepeleva and 5 other authors -
Independent component analysis of cancer transcriptomes: optimization of parameters and improvement of interpretability – 09/07/2020
M. Chepeleva and 3 other authors -
Identification of a blood-based protein biomarker panel for lung cancer detection – 01/06/2020
Victoria El Khoury and 22 other authors -
Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software – 13/01/2020
Magali Richard and 44 other authors -
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment – 01/12/2019
Simone Niclou and 21 other authors -
Genome-wide shRNA screen identifies candidate genes driving glioblastoma invasion – 01/11/2019
Anne Schuster and 9 other authors -
Intrinsic tumor plasticity in glioblastoma allows for recreation of stem like-states and efficient tumor cell adaveveion to new microenvironments – 01/11/2019
Anna Golebiewska and 12 other authors -
Connecting histopathology imaging and proteomics in kidney cancer through machine learning – 01/10/2019
Francisco Azuaje and 3 other authors -
Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients – 18/09/2019
Petr Nazarov and 8 other authors -
Power-law behavior of the alternative splicing of exons in human transcriptome – 02/09/2019
Vasily V. Grinev and 2 other authors -
Independent component analysis for unraveling the complexity of cancer omics datasets – 01/09/2019
Andrei Zinovyev and 11 other authors -
Genome-wide shRNA screen identifies candidate genes driving glioblastoma invasion – 03/08/2019
Anne Schuster and 9 other authors -
A 3D brain organoid coculture system delineates the invasive cell components in glioblastoma – 01/08/2019
Wenjing Zhou and 11 other authors -
Intrinsic tumor plasticity in glioblastoma allows for recreation of stem like-states and efficient tumor cell adaptation to new microenvironments – 01/08/2019
Anna Golebiewska and 12 other authors -
Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity – 28/05/2019
Elisabeth Letellier and 11 other authors -
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses – 05/03/2019
Francisco Azuaje and 8 other authors -
RNAi/CRISPR Screens – 01/01/2019
Anne Schuster and 6 other authors -
A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma – 01/01/2019
Eric Van Dyck and 11 other authors -
Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer – 28/08/2018
Victoria El Khoury and 13 other authors -
Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach – 07/06/2018
Francisco Azuaje and 7 other authors -
Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways – 01/12/2017
Simone Niclou and 16 other authors -
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish – 31/05/2016
Francisco Azuaje and 17 other authors -
What do we learn from spheroid culture systems? Insights from tumorspheres derived from primary colon cancer tissue – 08/01/2016
Komal Qureshi-Baig and 6 other authors -
Whole transcriptome microarrays identify long non-coding RNAs associated with cardiac hypertrophy – 01/09/2015
Yvan Devaux and 9 other authors -
Verification of the biomarker candidates for non-small-cell lung cancer using a targeted proteomics approach – 06/03/2015
Bruno Domon and 7 other authors -
Transcriptional response to cardiac injury in the zebrafish – 03/10/2014
Francisco Azuaje and 9 other authors -
Technical considerations for large-scale parallel reaction monitoring analysis – 04/04/2014
Bruno Domon and 3 other authors -
Correction – 18/04/2013
Zsuzsa Rakosy and 10 other authors -
Use of circulating microRNAs to diagnose acute myocardial infarction – 01/03/2012
Daniel Wagner and 10 other authors -
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia – 19/04/2011
Etienne Moussay and 10 other authors -
Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
Jonathan Turner and 10 other authors -
Corrigendum to ‘Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model’ [Ultrasound in Med & Biol. 49 (2023) 1082-1090, (S0301562922006664), (10.1016/j.ultrasmedbio.2022.12.006)] – 01/01/2024
Yanrong Zhang and 13 other authors -
Immune cell identity behind the Ktrans mapping of mouse glioblastoma – 21/06/2023
Max Wintermark and 13 other authors -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model – 01/01/2023
Max Wintermark and 13 other authors -
Author Correction – 26/01/2023
Spyridon Bakas and 278 other authors -
Federated learning enables big data for rare cancer boundary detection – 05/12/2022
Spyridon Bakas and 278 other authors -
Deciphering Human Glioblastoma Invasion Using a Developmental Mature Rat Brain Organoid Model – 15/11/2022
Wenjing Zhou and 30 other authors -
The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
Bassam Janji and 7 other authors -
Federated Learning Enables Big Data for Rare Cancer Boundary Detection – 22/04/2022
Spyridon Bakas and 278 other authors -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia after MRgFUS induced BBB Opening in a Mouse Glioblastoma Model – 15/03/2022
Max Wintermark and 13 other authors -
Relationship between Metabolically Unhealthy Obesity and Visceral Adipose Tissue in Youth – 01/12/2021
Hanène Samouda and 5 other authors -
Inhibition of GBM invasion by the A-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid (AMPA) Glutamate receptor antagonist Perampanel – 09/09/2021
Katharina Sarnow and 3 other authors -
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy – 01/09/2021
Max Wintermark and 13 other authors -
Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors – 18/06/2021
Anaïs Oudin and 16 other authors -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
Simone Niclou and 40 other authors -
Is there a prominent role for MR spectroscopy in the clinical management of brain tumors? – 01/07/2020
Simone Niclou and 1 other author -
Spatially regularized estimation of the tissue homogeneity model parameters in DCE-MRI using proximal minimization – 01/12/2019
Michal Bartos and 5 other authors -
Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood–brain barrier – 01/11/2019
Frits Thorsen and 17 other authors -
THER-11. Peptide mediated permeabilization of the blood-brain-barrier improves drug delivery to brain metastasis – 01/08/2019
Synnøve Nymark Aasen and 17 other authors -
Improved treatment of melanoma brain metastasis using a synthetic peptide – 01/11/2018
Synnove Nymark Aasen and 14 other authors -
Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma – 01/10/2018
Olivier Keunen and 9 other authors -
EGFL7 enhances surface expression of integrin α 5 β 1 to promote angiogenesis in malignant brain tumors – 01/09/2018
Mirko H.H. Schmidt and 17 other authors -
The good drug, the bad barrier and the handy peptide: Improved treatment of experimental melanoma brain metastases using a synthetic peptide – 01/07/2018
Synnove Nymark Aasen and 10 other authors -
Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways – 01/12/2017
Simone Niclou and 16 other authors -
Subtraction of subcutaneous fat to improve the prediction of visceral adiposity – 01/08/2017
Hanène Samouda and 9 other authors -
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation – 01/12/2016
Hrvoje Miletic and 29 other authors -
Cardiometabolic risk – 01/06/2016
Hanène Samouda and 11 other authors -
Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma – 31/05/2016
Simone Niclou and 18 other authors -
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma – 27/11/2015
Eyal Gottlieb and 19 other authors -
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas – 17/01/2015
Rolf Bjerkvig and 18 other authors
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CANBIO
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i2TRON
TTM is taking a leading role in the coordination of i2TRON, a doctoral training unit (DTU) with a strong focus on developing the new generation of translational scientists, who can turn observations in the laboratory, clinical setting or community into interventions that improve the health of individuals via innovative diagnostics or treatments.
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Job vacancies
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Post-Doctoral Fellow in brain tumor metabolism: tumour heterogeneity and resistance mechanisms (JA/PD0624/AG/NORLUX)
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Post-doctoral position in Cancer Metabolism Research (MC/PDTSI/0724/EMJP)
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PhD student in Cancer Research (MC/PHD0724/TSI/EMJP)
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