Department of Infection and Immunity 

The Department aims to understand the complex mechanisms of infectious and inflammatory disease processes in order to enable new ways to diagnose, prevent or cure human diseases. Such a strategy requires the existence of a highly interdisciplinary research environment with intensive collaboration of basic and clinical immunologists, engineers, biochemists, computational and systems biologists, public health specialists and clinician scientists. 

activities

The Department of Infection and Immunity (DII) defines itself as a clinical-translational research center at the crossroads of basic discovery, clinical application, and public health service. 

As such, the major focus of DII is on the analysis of complex mechanisms of infectious and inflammatory disease processes. With a multi-disciplinary approach, the research strategy is based on the following elements: experimental discovery, bridging to clinical application and technology development. Major unsolved medical questions in the areas of inflammation (allergy, asthma, autoimmunity), cancer and infectious diseases (HIV) drive DII’s current and future research agenda. The long-term objective of the DII is to develop into a center of complex immune system analysis in order to provide a better understanding of immune-mediated disease pathologies and infectious diseases.

Director of department

The establishment of the Department of Infection and Immunity was concluded in September 2014 with the appointment of Markus Ollert as its inaugural director. 

Prof Markus Ollert has long-term expertise in the field of Allergy and Dermatology. Markus Ollert was appointed full professor and faculty member at Odense University Hospital of the University of Southern Denmark in January 2015. 

Markus
Ollert

Projects & clinical trials

Immune Endocrine and Epigenetics
DNA Methylation: Conducting the orchestra from exposure to phenotypes
Immune Endocrine and Epigenetics Metabolic Diseases
MAternal Diabetes and neuropsychiAtric vulnerability in offspring: role of DNAmethylation
Immune Endocrine and Epigenetics Immunological Disorders
LONG TERM IMMUNOLOGICAL CONSEQUENCES IN ADVERSITY-DIVERGENT TWINS
Cancer
Modulation of cytokine pathways for allergy specific immunotherapy
Immuno-Pharmacology and Interactomics Cancer
Development of chemokine receptor modulators for improved cancer immunotherapy
Cancer
Pre-clinical evaluation of immunoconjugates activating NK cells in cancer models
Immune Endocrine and Epigenetics
Age Acceleration and the Life Course
Immunological Disorders Precision Health
NEXT GENERATION IMMUNOSCIENCE: Advanced Concepts for Deciphering Acute and Chronic Inflammation
Cancer
Molecular mechanisms of chronic inflammation connected to cancer development
Immune Endocrine and Epigenetics Immunological Disorders
Early-life immune programming
Experimental and Molecular Immunology Immunological Disorders
Reactive Oxygen Species (ROS) Metabolism –Turning the Sword Against Lymphoma
Experimental and Molecular Immunology Immunological Disorders
Elucidating the role of susceptibility pathways during bacterial-induced colitis
Immuno-Pharmacology and Interactomics Immunological Disorders
Validation of chemokine receptor isoforms as drug targets for cancer therapy using Nanobody technology
Immunological Disorders
Murine model of tolerance to adjuvant-driven allergen-specific immunotherapy
Immuno-Pharmacology and Interactomics Cancer
Expression and functional characterization of the CXCR3-CXCR7heterodimer in glioblastoma
Immuno-Pharmacology and Interactomics Cancer
Nanobody-enabled structural and functional studies of Chemokine-CCR5 active-state complexes
Immuno-Pharmacology and Interactomics Cancer
Multidimensional regulation of the opioid network by ACKR3
Immuno-Pharmacology and Interactomics Cancer
Unraveling the role of the ACKR3/CXCR7 receptor in glioblastoma cells survival and invasion in the tumor relapse.
Immuno-Pharmacology and Interactomics Cancer
Targeting chemokine receptors for improved cancer immunotherapy
Immuno-Pharmacology and Interactomics
Evaluation of LIH383 as a new neuro-pharmacological modulator
Immuno-Pharmacology and Interactomics Cancer
Megakines – novel tools for structural insight into receptor:chemokine complexes
Immuno-Pharmacology and Interactomics Cancer
Megakines – novel tools for structural insight into receptor:chemokine complexes
Immuno-Pharmacology and Interactomics Cancer
Assessment of SARS-CoV-2neutralizing antibodies inLuxembourg through novel highlysensitive NanoLuciferase-basedhigh throughput assays
Experimental and Molecular Immunology Immunological Disorders
Metabolic gatekeepers in T cells: Decision making and controlling inflammation in vivo
Immunological Disorders
A humanized mouse model of HIV latency as a preclinical tooltowards functional HIV cure
Cancer
Predictingthein vivoactivation potential of Th2 cells of patients
Proteomics of Cellular Signaling Cancer
The exosome proteome as a source of non-invasive biomarkers in solid tumours
Deep Digital Phenotyping Research Unit Cardiovascular Research Unit
Luxembourg cohort of positive patients for COVID-19: a stratification study to predict severe prognosis
Experimental and Molecular Immunology Immune Endocrine and Epigenetics
COvid-19 National survey for assessing Viral spread by Non-affected Carriers
Immuno-Pharmacology and Interactomics Cancer
Targeting chemokine receptors: An innovative strategy to reprogram cold to hot tumor microenvironment and to improve PD-1-based cancer immunotherapy
Human Biomonitoring Research Unit Nutrition, Microbiome and Immunity
Effects of pesticides on the gut and their role in cancer development
Nutrition, Microbiome and Immunity Immunological Disorders
Dietary fiber-deprived gut microbiota in Inflammatory Bowel Disease (IBD)
Nutrition, Microbiome and Immunity Immunological Disorders
Fiber-deprived gut microbiota erodes the colonic mucus barrier: understanding immune dysregulation, pathogen susceptibility and prospects for improvement using prebiotics
Nutrition, Microbiome and Immunity Immunological Disorders
Functional characterization of COVID-19 patient gut microbiome
Nutrition, Microbiome and Immunity NutriHealth
From mouse to man: translating findings in mouse study into a human cohort (Luxembourgish Fiber Cohort: Lux-FiCo)
Nutrition, Microbiome and Immunity Immunological Disorders
Dietary-fiber mediated gut homeostasis: interaction of the microbiome with the colonic mucus barrier
Nutrition, Microbiome and Immunity Immunological Disorders
Mucobiomes in the pathogenesis of inflammatory bowel disease
Nutrition, Microbiome and Immunity Immunological Disorders
MUCOBIOME-MEDIATED IMMUNE PATHWAYS IN INFLAMMATORY BOWEL DISEASES
Nutrition, Microbiome and Immunity Experimental and Molecular Immunology
Regulatory T cell responses at the crossroads of immune homeostasis and inflammation in the context of barrier diseases
Immunological Disorders
Casamance Research-program on HIV-Resistance and Sexual health
Cancer Immunological Disorders
Therapeutic and Safety Evaluation of the CoMiX immunoconjugates as a novel complement activation-based immunotherapy strategy
Covid-19 – Infectious Diseases
Comparing the technical performances of three real-time PCRs to counteract the COVID-19 outbreak in Luxembourg
Immunological Disorders Covid-19 – Infectious Diseases
Support au Laboratoire de Rétrovirologie, HIV-Clinical and Translational Research group
Immunological Disorders Covid-19 – Infectious Diseases
The humanized mouse model of HIV latency as a preclinical tool for therapeutic vaccine and anti-latency agent development.
Immunological Disorders Covid-19 – Infectious Diseases
Plan national de lutte contre le VIH/SIDA et les IST
Covid-19 – Infectious Diseases
Prévention transmission covid-19
Immunological Disorders Covid-19 – Infectious Diseases
Real-time molecular surveillance to prioritize HCV treatment in injecting drug users
Immunological Disorders Cancer
From Systemic Lupus Erythematosus to Cancer: role of the Mutator Enzyme APOBEC3A in auto-immunity and tumorigenesis
Covid-19 – Infectious Diseases
A novel high throughput assay to measure plasma NEUTRalizing Activity against SARS-CoV-2 against SARS-CoV-2
Clinical and Applied Virology Covid-19 – Infectious Diseases
Surveillance and characterization of important livestock and zoonotic viruses in Luxembourg
Proteomics of Cellular Signaling Covid-19 – Infectious Diseases
Early detection of COVID19-induced tissue damage and (hyper)inflammation from serum samples
Proteomics of Cellular Signaling
Clinical Proteomics Initiative Luxembourg
Proteomics of Cellular Signaling Cancer
Development of a personalised non-invasive diagnosis of endometrial cancer
Proteomics of Cellular Signaling Cancer
Hif-α non-canonical regulation by PTMs and new interaction partners
Proteomics of Cellular Signaling
Next-generation of multi-omics research: going to the single cell
Proteomics of Cellular Signaling Cancer
Comprehensive analysis of the Hif1α interactome and its regulation by post-translational modifications
Proteomics of Cellular Signaling Cancer
Spatio-temporal analysis of TGFβ receptor signalling and trafficking studied by peroxidase-mediated quantitative proximity proteomics and correlative imaging
Clinical and Applied Virology Covid-19 – Infectious Diseases
Role of COmpanion and LIVEstock animals in the epidemiology of SARS-CoV
Clinical and Applied Virology Covid-19 – Infectious Diseases
The value of sewage surveillance to provide new insights on the circulation of SARS-COV-2 and to reveal the true extent of the coronavirus pandemic at the national scale
Clinical and Applied Virology Covid-19 – Infectious Diseases
Risk assessment for influenza D in Europe
Clinical and Applied Virology Covid-19 – Infectious Diseases
Developing an integrated approach to assess the emergence threat associated with influenza D viruses’ circulating in Europe
Clinical and Applied Virology Covid-19 – Infectious Diseases
Environmental-based epidemiology for preparedness and early detection of viral epidemics
Immunological Disorders
Immunodeficiency with autoimmunity: unravelling the molecular origin of Good’s syndrome
Immune Endocrine and Epigenetics Immunological Disorders
Microbiomes in One Health
Nutrition, Microbiome and Immunity Immunological Disorders
Microbiomes in One Health
Immuno-Pharmacology and Interactomics Cancer
Study of the CXCL12-CXCR4/ACKR3 signaling in glioblastoma and of its importance in the control of translation and relapses
Immuno-Pharmacology and Interactomics Tumor Stroma Interactions
Role of chemokine receptor-bearing extracellular vesicles in leukaemia and lymphoma
Experimental and Molecular Immunology Immunological Disorders
The Next Generation Immunoscience
Immuno-Pharmacology and Interactomics Cancer
Regulation of glioblastoma growth and tumor microenvironment by receptors ACKR3 and CXCR4
Immuno-Pharmacology and Interactomics
Multilevel regulation and modulation of the new opioid peptide scavenger ACKR3
Nutrition, Microbiome and Immunity
MICROBIOME-BASED BIOMARKERS AS PERSONALISED RISK FACTORS OF DISEASE
Immune Endocrine and Epigenetics Cancer
Epigenetic control of effector lymphocyte function
NutriHealth Nutrition, Microbiome and Immunity
Interactions of carotenoids and dietary fiber – implications for bioavailability and colonic degradation
Immune Endocrine and Epigenetics
The effects of childhood adversity on mental health and learning: A nationwide longitudinal project with children in alternative care in Luxembourg
Proteomics of Cellular Signaling
Lecture series on multi-omics techniques
Experimental and Molecular Immunology Covid-19 – Infectious Diseases
Coronavirus antigen array for parallelized serological profiling
Covid-19 – Infectious Diseases
Development and validation of a SARS-CoV-2 variant surrogate Viral Neutralization Test (sVNT)
NutriHealth Nutrition, Microbiome and Immunity
Empowering Healthy Lifestyle Behaviour Through Personalized Intervention Portfolios To Prevent And Control Obesity During Vulnerable Stages Of Life
Covid-19 – Infectious Diseases
PSEUDO: Pre-clinical validation of CoMiX and Bikes/Trikes against infections with Pseudomonas aeruginosa
Proteomics of Cellular Signaling Immunological Disorders
Regulation of the T-cell immune response by post-translational modifications
Nutrition, Microbiome and Immunity Immunological Disorders
Dietary fiber, the gut microbiome and the immune system
Immuno-Pharmacology and Interactomics Immunological Disorders
Unravelling the multidimensional regulation of the chemokine functions in health and disease with network-wide approaches
Clinical and Applied Virology Covid-19 – Infectious Diseases
Epidemiological determinants of infectious diseases in Children, Lao PDR 2023-2025
Experimental and Molecular Immunology Immunological Disorders
Mitochondrial metabolism: Deciphering new routes to control T cell function
Immune Endocrine and Epigenetics Immunological Disorders
NK cell senescence in adversity-divergent twins
Immune Endocrine and Epigenetics
Partnership for the assessment of risks from chemicals
Clinical and Applied Virology
Microbiology for development VI
Experimental and Molecular Immunology Immunological Disorders
Deciphering the Function of Mitochondrial Pyruvate Transport in T Cell-Mediated Immunity
Nutrition, Microbiome and Immunity
Mucin-degrading bacteria in ulcerative colitis: a translational approach
Immuno-Pharmacology and Interactomics
NanoLux Platform Mobility to Quebec
Immuno-Pharmacology and Interactomics
NanoLux platform
Translational & Clinical Immunology
Use of TNFR2 agonist antibody to enhance potent regulatory T cells in allergen-specific immunotherapy
Immuno-Pharmacology and Interactomics Cancer
Targeting the atypical chemokine receptor ACKR3 for improved cancer therapy
Experimental and Molecular Immunology Cancer
Anti-Tumour Immunity: Tuning metabolic circuits in T-cells to fight cancer.
Neuro-Immunology Group Cancer
Impact of the Adaptive Immunity on the Delayed Glioma Progression in a Mouse Model of Allergic Inflammation
Parkinson’s Disease Covid-19 – Infectious Diseases
COMorbidity Mechanisms UTilized in hEalthcare
Clinical and Applied Virology
Setting up a coordinated surveillance under the One Health approach
Experimental and Molecular Immunology Cancer
ldentification Of Clinically Relevant Compounds For The Enhancement Of Cd8 T Cell Metabolism And Function
Cancer
CRISPR screens in primary human CD8 central memory T cells identify regulators driving CD8 TEMRA differentiation
Experimental and Molecular Immunology
Lecture series in infection and immunity
Experimental and Molecular Immunology
Lecture Series in Infection & Immunity 2023
Experimental and Molecular Immunology
Lecture Series in Infection & Immunity 2022
Experimental and Molecular Immunology
Lecture Series 2019-2021 ‘Infection & Immunity’
Experimental and Molecular Immunology
Lecture Series 2018 ‘Infection & Immunity’
Experimental and Molecular Immunology
Lecture Series 2017 ‘Infection & Immunity’
Translational & Clinical Immunology
Biomolecular Module Assemblies as a Versatile and Potent Immune Modulator Platform
DIE-IBD Study: Are you interested in the composition of your intestinal microbiota?
Clinical and Applied Virology
Setting up a coordinated surveillance under the One Health approach
Experimental and Molecular Immunology Translational & Clinical Immunology
Lecture Series ‘Infection & Immunity’
Immuno-Pharmacology and Interactomics
Unravelling the multidimensional regulation of the chemokine functions in health and disease with network-wide approaches
Clinical and Applied Virology
Luxembourg-Laos Partnership for Research and Capacity Building in Infectious Disease Surveillance
Proteomics of Cellular Signaling
SPATIAL TARGETED PROTEOMICS USING PASEF-PRM
Molecular and Translational Allergology
Exploring early immune mechanisms of food allergic reactions in humans to develop markers and treatment targets
Immuno-Pharmacology and Interactomics Immunological Disorders
Identifying Molecular Patterns of Atypical Chemokine Receptors for Translational Targeting
Integrated Biobank of Luxembourg (IBBL) Translational & Clinical Immunology
Applying systems immunology to the search for personalized biomarkers of clinical efficacy: Predicting the T cell activation potential in vivo from resting T cells of patients
Identification of network markers to predict T cell activation potential of individuals following ultra-rush subcutaneous immunotherapy for wasp venom allergy
Multiomics Data Science Proteomics of Cellular Signaling
Personalized Medicine Acceleration through Rapid Omics Profiling
Regulation of the allergic airway Th2 response by redox metabolism
Nutrition, Microbiome and Immunity
Personalized Food Response Models
Immuno-Pharmacology and Interactomics
Molecular and functional characterization of CXCR7 and its unconventional ligands MIF and ADM and their roles in virus-associated tumorigenesis
Molecular and Translational Allergology Immunological Disorders
Seizing The Allergy Burden In Luxembourg: Allergen-resolved Deep IgE-profiles In A Representative Population-based, Cross-sectional Health Survey
Proteomics of Cellular Signaling Parkinson’s Disease
The role of ER-mitochondria signalling in Parkin-associated Parkinson´s disease
Molecular and Translational Allergology
Eat or not to eat – food allergy explained
Infection and Immunotherapy Reseach Group
ROSETTA: A global registry on second generation and long-acting integrase inhibitor failures.
Molecular and Translational Allergology Immunological Disorders
Integrative approach to identify drivers of acute immune responses in food allergy
Molecular and Translational Allergology Immunological Disorders
Markers of shaping and educating the early life immune response to food proteins
Proteomics of Cellular Signaling NORLUX Neuro-Oncology Laboratory
MS-based proteomic approach to characterize phosphosignaling in glioblastoma
Immunological Disorders Covid-19 – Infectious Diseases
Microbiomes in One Health
Infection and Immunotherapy Reseach Group
I2TRON Camille Rolin: PRE-CLINICAL EVALUATION OF IMMUNOCONJUGATES ACTIVATING NK CELLS IN DIFFERENT CANCER MODELS
Immuno-Pharmacology and Interactomics NORLUX Neuro-Oncology Laboratory
SMART GLIOBLASTOMA: Signaling and Modulation of the AtypicalIsoform of the CXCR3 RecepTor in glioblastoma cells
Molecular and Translational Allergology
ALLPRET: Allergenicity prediction toolbox for novel foods
Infection and Immunotherapy Reseach Group
Interventions towards functional cure: detailed phenotyping of the HIV-specific polyfuntional CD8+ T cell response of controllers for therapeutic vaccine design
Molecular and Translational Allergology Immunological Disorders
IRGal 2017: Targeting Key Factors Involved in Immune Reactions mediated by Tick Bites to the Carbohydrate alpha-Gal
Infection and Immunotherapy Reseach Group
Conseil Supérieur des maladies infectieuses
Cytoskeleton and Cancer Progression Proteomics of Cellular Signaling
Targeting a key promoter of multiple pro-metastatic pathways in breast cancer
Molecular and Translational Allergology Immunological Disorders
RespAll: Molecular sensitization patterns to established and novel allergens from furry animals
Molecular and Translational Allergology Immunological Disorders
Profiling the interaction of mammalian respiratory allergens with cells of the epithelial interface
Molecular and Translational Allergology
Care4Asthma: Advancing diagnosis and treatment of paediatric asthma by digital technology and deep immunophenotyping
Molecular and Translational Allergology Immunological Disorders
Immune profiling the blood and the gut microbiome: Advanced population- and patient-based stratification for tackling the allergy epidemic
Molecular and Translational Allergology Immunological Disorders
NOR-BRA: NORWEGIAN BIRCH RUST ALLERGY STUDY
Molecular and Translational Allergology Immunological Disorders
Identification of immunologically active peptides from food allergens in sera of allergic patients
Molecular and Translational Allergology Immunological Disorders
APSIS: Paving the way for novel personalized medicine approaches to diagnose and cure food allergies
Molecular and Translational Allergology Immunological Disorders
Characterization and modulation of fish allergenicity towards the production of a low allergen farmed fish
Molecular and Translational Allergology Covid-19 – Infectious Diseases
COV-Immun: Development of a high performance COVID-19 immunoassay, an essential tool to establish immunity passports in the Luxembourgish population
Molecular and Translational Allergology Immunological Disorders
Interaction of the lung microbiome with airway epithelial and immune cells
Molecular and Translational Allergology Immunological Disorders
7th international Symposium on Molecular Allergology
Molecular and Translational Allergology Immunological Disorders
Allergy and autoimmunity based project(s)
View all projects on our research portal

Featured team members

  • Sarah
    Alhamouieh     PhD Student
  • Isabela
    Assugeni     PhD Student
  • Murilo
    Bazon     Postdoctoral Fellow
  • Safiya
    Benharrat     Laboratory Technician
  • Carole
    Binsfeld     Laboratory Technician
  • Dirk
    Brenner     Group Leader and Deputy Head Research & Strategy, Department of Infection and Immunity
  • Theresa-Maria
    Böhm     PhD Student
  • Emilie
    Charpentier     Laboratory Technician
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TTM is taking a leading role in the coordination of i2TRON, a doctoral training unit (DTU) with a strong focus on developing the new generation of translational scientists, who can turn observations in the laboratory, clinical setting or community into interventions that improve the health of individuals via innovative diagnostics or treatments. 

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