🇬🇧 Mitochondria at the hub of cell death and immunity in irradiated cancer cells

• Lecture Series Cancer Research

• Webinar
• Département de Recherche sur le Cancer

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Speakers

Prof. Lorenzo
Galluzzi

Associate Professor, Fox Chase Cancer Center (Philadelphia, PA, US), Honorary Assistant Professor Adjunct, Yale School of Medicine (New Haven, CT, US), Faculty, University of Ferrara Graduate School
(Ferrara, IT), Faculty, University of Padova Graduate School (Padova, IT), Faculty, University of Roma “La Sapienza” Graduate School (Roma, IT), Associate Director, European Academy for Tumor Immunology

Abstract

Immunogenic cell death (ICD) is a functionally defined form of regulated cell death that culminates in the initiation of adaptive immune responses with an active effector phase. Radiation therapy (RT) is a bona fide ICD inducer, as
demonstrated preclinically in both prophylactic vaccination assays and in abscopal tumor models. The ability of RT to drive ICD critically impinges on
type I interferon (IFN) secretion by irradiated cancer cells. We demonstrated that ICD elicited by RT in preclinical models of HR+ breast cancer requires mitochondrial outer membrane permeabilization (MOMP) and is tonically
inhibited by mitophagy and caspases.

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Protection des données

En savoir plus sur la « Notice sur la protection des données : traitement des données personnelles dans le cadre de la gestion des événements  ».