🇬🇧 Revealing protein diversity by mass spectrometry: Post-translational modifications in cell signaling and chromatin biology » Luxembourg Institute of Health
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🇬🇧 Revealing protein diversity by mass spectrometry: Post-translational modifications in cell signaling and chromatin biology

08/11/2023 11:00 Ă  13:30
  • Lecture Series Infection & Immunity – Next-generation of multi-omics research:going to the single cell

Speakers

Prof. Ole
Nørregaard Jensen

Professor at the University of Southern Denmark, SDU
President and Founding member, Danish Proteomics Society (DAPSOC)

Many dynamic biochemical processes in the cell are controlled by proteins. Protein activity and interactions are accurately modulated by regulatory (reversible) chemical modifications of distinct amino acids in proteins, known as post-translational modifications (PTMs). My laboratory develops and applies mass spectrometry technologies to study proteins and their PTMs. I will describe a series of examples from past and current research to demonstrate the capabilities of mass spectrometry to identify and quantify PTMs in complex biological systems. I will focus on protein phosphorylation and on regulatory modifications of histones in chromatin. I will introduce different approaches to PTM-mapping of proteins, covering bottom-up, middle-down and top-down protein analysis strategies for detailed characterization of protein diversity. Recently, ion mobility spectrometry has proven useful for separation of near-identical protein species, as illustrated by detection of different acetylated histone H4 proteoforms generated by the KAT8 acetyltransferase.


Responsible Scientist
Gunnar
Dittmar

LOCATION

Maison du Savoir, Uni LU
Room: MSA 4.320

2, Av. de l’UniversitĂ©, Belval Esch-sur-Alzette

LECTURE: 11:00am – 12:00pm

Please note that registration is mandatory by sending an email to carole.weis@lih.lu or michelle.roderes@lih.lu

MEET & EAT

12:00pm – 13:30pm

LCSB
Kitchenette 2nd floor

29, rue Henri Koch, L-4354 Esch-sur-Alzette

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