🇬🇧 Metabolic requirement of regulatory B cells and plasma cells in health and disease

Abstract

Regulatory B cells (Bregs) are an immunosuppressive subset of B cells that restore homeostasis following inflammatory responses, primarily via the provision of IL-10.

Bregs have been shown to be numerically and functionally decreased in autoimmunity whilst enriched in primary solid tumors. While the field of immunometabolism is rapidly expanding little is understood about Breg
metabolic requirements. Understanding the metabolic requirement of Bregs over other B cells subsets which may shed light on the dysregulation of this cell subset in disease and provide novel therapeutic targets.

I will present an historical view of Bregs function, and the signals required for their differentiation. I will also share more recent data characterising how Bregs meet their metabolic demands in response to inflammation and how
this can be manipulated for the restoration of B cell responses in patients with SLE.