Initiative « COST » dans le cadre de EU-CardioRNA : le LIH joue un rôle de premier plan dans la recherche collaborative internationale sur les maladies cardiaques

Veuillez noter qu’à l’exception du titre et du résumé, cet article est uniquement disponible en anglais.

• Unité de Recherche Cardiovasculaire

Le LIH est non seulement un partenaire de recherche privilégié au Luxembourg, mais jour aussi un rôle de premier plan aussi dans le monde entier lors d’initiatives de collaboration à grande échelle. L’un des exemples les plus récents est l’initiative « COST CA17129 » de UE-CardioRNA (EU-CardioRNA – www.cardiorna.eu), qui vise à comprendre le rôle complexe de la transcriptomique dans les maladies cardiovasculaires.

Founded at the end of 2018, the EU-CardioRNA network just celebrated its second anniversary. It includes 180 members from 36 European and partner countries. The collaborative network brings together academic researchers, clinicians, and industrial partners with multidisciplinary expertise ranging from basic research to clinical research and molecular diagnostics, from pharmacology to molecular biology and many other aspects of biology, from information technology to bioinformatics, biostatistics, and artificial intelligence. 

CARDIOVASCULAR DISEASE REMAINS A MAJOR CAUSE OF MORTALITY

The participating researchers are following the principles of translational medicine, which aims to use interdisciplinary activities to translate preclinical research into clinical development quickly and efficiently. This is essential in view of the worldwide spread of cardiovascular disease, as Dr. Yvan Devaux, Head of Cardiovascular Research Unit, LIH, and Chair of EU-CardioRNA COST Action, underlines: “Cardiovascular disease remains a major cause of mortality and disability in the modern world. Further translational research is needed to identify novel therapeutic targets and biomarkers to optimise healthcare and decrease the burden of cardiovascular disease.”   

POTENTIAL OF RNA MOLECULES IN DIAGNOSING AND TREATING PATIENTS

Transcriptomics are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts. While nearly 98% of human genes are transcribed into RNA molecules, very few (<3%) are able to encode proteins. Yvan Devaux: “Proteins have traditionally been at the centre of most research projects, whereas RNAs have received less attention. Yet, RNA molecules have the potential to aid in diagnosing, prognosticating, and treating patients with cardiovascular disease, in a personalised and sex-specific manner.” 

FUNDING SCHEME

The EU-CardioRNA COST Action is financed by COST association (Cooperation in Science and Technology), itself financed by the Horizon 2020 research and innovation program. Yvan Devaux’s leadership and coordinating role in the Action is financed by the Ministry of Higher Education and Research and the Fondation Coeur – Daniel Wagner.

REFERENCES

• Transcriptomics Research to Improve Cardiovascular Healthcare. The EU-CardioRNA COST Action. Lina Badimon, Yvan Devaux, European Heart Journal, Volume 41, Issue 35, 14 September 2020, Pages 3296–3298
• EHJ Cardiopulse article ‘Transcriptomics Research to Improve Cardiovascular Healthcare’
• www.cardiorna.eu