Département de recherche sur le cancer
Notre vision est d’améliorer la vie des patients en faisant progresser la lutte contre le cancer. Forts d’un solide palmarès scientifique, nous nous concentrons sur des domaines de recherche prioritaires et fournissons une expertise en matière de recherche couvrant les types de cancers les plus fréquents ou les plus agressifs et qui constituent un fardeau pour les services de santé au Luxembourg. Le département constitue également un lieu de formation de pointe pour la prochaine génération de chercheurs en cancérologie et jour le rôle de point de référence pour la recherche sur le cancer au Luxembourg.
Mission
La mission principale du Département de recherche sur le cancer (Department of Cancer Research – DOCR) est de faire progresser les possibilités de traitement du cancer et de réduire la charge du cancer au sein de la population luxembourgeoise et au-delà. Nous y parvenons grâce à l’excellence de nos recherches dans des domaines prioritaires couvrant le paysage de la recherche fondamentale, translationnelle et clinique, afin de promouvoir les programmes de médecine personnalisée. Nos activités se concentrent sur les cancers difficiles à traiter et nos équipes disposent d’une expertise spécifique en matière d’immunologie des cancers, de microenvironnement tumoral, de métabolisme tumoral et de neuro-oncologie. Nous explorons les mécanismes cellulaires et moléculaires de la progression tumorale à l’aide d’un large éventail de technologies de pointe, notamment de technologies omiques multimodales (génomique, métabolomique…), d’analyses de profilage immunologique avancées, ainsi que de modalités d’imagerie ex vivo et in vivo exploitant des données de patients et des modèles innovants dérivés de patients à des fins de recherche en cancérologie.
DIRECTEUR DU DÉPARTEMENT
Meiser
- Centre de Neuropathologie du Luxembourg
- Cytosquelette et Progression du Cancer
- Groupe Immunothérapie et microenvironnement des tumeurs
- Groupe Métabolisme du Cancer
- Groupe Neuro-immunologie
- Interactions Tumoral Stroma
- Laboratoire de Neuro-oncologie NORLUX
- Plateforme D’imagerie in Vivo
- Radiomique Translationnelle
- Réparation de l’ADN et Chimiorésistance
- Science des Données Multi-omiques
Projets et essais cliniques
Membres de l’équipe
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Rafael
Barros Laboratory Assistant -
Elisabetta
Bartolini PhD Student -
Michaela
Bauer Postdoctoral Fellow -
Amandine
Bernard Laboratory Technician -
Coralie
Borne Postdoctoral Fellow -
Selma
Boudissa Research Engineer -
Eleonora
Campus PhD Student -
Maryna
Chepeleva PhD Student -
Valentina
Delli Zotti Visiting Researcher -
Chloé
Duculty PhD Student -
Iria
Fernandez Botana Postdoctoral Fellow -
Liza
Filali Postdoctoral Fellow -
Ruize
Gao Postdoctoral Fellow -
Melike
Gezen Postdoctoral Fellow -
Ozgu
Gumustekin PhD Student -
Céline
Hoffmann Scientist -
Wanxin
Huang PhD Student -
Bassam
Janji Group Leader -
Maxmilan
Jeyakumar Postdoctoral Fellow -
Georgia
Kanli Research Engineer -
Olivier
Keunen Group Leader -
Vanessa
Klapp PhD Student -
Akinchan
Kumar Postdoctoral Fellow -
Anne
Largeot Scientist -
Frida
Lind-Holm PhD Student -
Beatrice
Melin Visiting Researcher -
Takouhie
Mgrditchian Postdoctoral Fellow -
Alessandro
Michelucci Group Leader -
Flora
Moreau Laboratory Technician -
Etienne
Moussay Group Leader -
Petr
Nazarov Group Leader -
Bakhtiyor
Nosirov Postdoctoral Fellow -
Jérôme
Paggetti Group Leader -
Valérie
Palissot Scientist -
Diogo
Pereira Fernandes PhD Student -
Daniele
Perlo Postdoctoral Fellow -
Michaela
Pešová Postdoctoral Fellow -
Sandrine
Pierson Research Engineer -
Aurélie
Poli Scientist -
Margaux
Poussard Postdoctoral Fellow -
Teresa
Ramos Postdoctoral Fellow -
Lucie
Rospape PhD Student -
Francesca Maria
STEFANIZZI Postdoctoral Fellow -
Andrea
Scafidi PhD Student -
Danial
Tabbakh PhD Student -
Clément
Thomas Group Leader -
Reka
Toth Scientist -
Kris
Van Moer Research Engineer -
Alice
Verdier PhD Student -
Elodie
Viry Postdoctoral Fellow -
Guillaume
Vogin Clinician Scientist
Publications scientifiques
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Is the tumor cell side of the immunological synapse a polarized secretory domain? – 24/09/2024
Clément Thomas et 6 autres auteurs -
A comprehensive guide to study the immunological synapse using imaging flow cytometry – 03/04/2024
Céline Hoffmann et 3 autres auteurs -
Actin remodeling in autophagy-mediated tumor immune escape, mechanistic aspects – 08/12/2023
Andrea Michela Biolato -
CSPG4 CAR-redirected Cytokine Induced Killer lymphocytes (CIK) as effective cellular immunotherapy for HLA class I defective melanoma – 22/11/2023
Dario Sangiolo et 26 autres auteurs -
Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse – 21/09/2023
Clément Thomas et 4 autres auteurs -
Correlative light and electron microscopy to explore the lytic immunological synapse between natural killer cells and cancer cells – 05/06/2023
Felix K Borgmann et 4 autres auteurs -
The Immunological Synapse Part B – 11/07/2023
Clément Thomas et 1 autre auteur -
Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus – 15/05/2023
Clément Thomas et 10 autres auteurs -
Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse – 28/04/2023
Salvatore Valitutti et 3 autres auteurs -
An integrated workflow for phosphopeptide identification in natural killer cells (NK-92MI) and their targets (MDA-MB-231) during immunological synapse formation – 09/02/2023
Gunnar Dittmar et 3 autres auteurs -
The Immunological Synapse Part A – 11/01/2023
Clément Thomas et 1 autre auteur -
Ultrarapid lytic granule release from CTLs activates Ca2+-dependent synaptic resistance pathways in melanoma cells – 01/02/2022
Salvatore Valitutti et 13 autres auteurs -
Tumour Immune Evasion is Promoted by Actin Cytoskeleton-Driven Polarization of Inhibitory Signals to the Immunological Synapse – 09/09/2021
Hannah Wurzer -
How natural killer cells avoid self-destruction when killing their targets – 01/08/2021
Clément Thomas et 2 autres auteurs -
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling – 24/05/2021
Clément Thomas et 11 autres auteurs -
Actin Cytoskeleton in Cancer Progression and Metastasis – Part C – 04/05/2021
Clément Thomas et 1 autre auteur -
Illuminating the signaling enigma of Carvedilol – 01/03/2021
Tobias Benkel et 21 autres auteurs -
The multiple roles of actin-binding proteins at invadopodia – 01/01/2021
Clément Thomas et 4 autres auteurs -
Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies – 09/11/2020
Clément Thomas et 4 autres auteurs -
Actin Cytoskeleton in Cancer Progression and Metastasis – Part B – 12/10/2020
Clément Thomas et 1 autre auteur -
Escape of tumor cells from the NK cell cytotoxic activity – 01/10/2020
Massimo Vitale et 3 autres auteurs -
Actin Cytoskeleton in Cancer Progression and Metastasis – Part A – 25/08/2020
Clément Thomas et 1 autre auteur -
The role of heparan sulfate maturation in cancer – 01/05/2020
Sandrine Gulberti et 2 autres auteurs -
Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasion from cytotoxic lymphocytes – 01/01/2020
Andrea Michela Biolato et 6 autres auteurs -
Do tumor cells escape from natural killer cell cytotoxicity by mimicking dendritic cells? – 29/03/2019
Clément Thomas et 3 autres auteurs -
Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2 – 01/12/2018
Clément Thomas et 9 autres auteurs -
Actin cytoskeleton remodeling drives breast cancer cell escape from natural killer-mediated cytotoxicity – 01/10/2018
Clément Thomas et 13 autres auteurs -
Role of the actin cytoskeleton in breast cancer cell resistance to natural killer cells – 06/07/2018
Antoun Al Absi -
Reactivation of mutant-EGFR degradation through clathrin inhibition overcomes resistance to EGFR tyrosine kinase inhibitors – 15/06/2018
Ludovic Ménard et 3 autres auteurs -
CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT – 03/04/2018
Bassam Janji et 10 autres auteurs -
Driving cytotoxic natural killer cells into melanoma – 01/01/2018
Bassam Janji et 8 autres auteurs -
Subcellular localization and function of 2LIM proteins in plants and humans – 01/12/2017
Clément Thomas et 2 autres auteurs -
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner – 31/10/2017
Bassam Janji et 15 autres auteurs -
The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer – 22/09/2016
Sylvie Fournel-Gigleux et 13 autres auteurs -
Digital skills for health professionals – 01/06/2016
F. Dalati et 10 autres auteurs -
TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics – 01/04/2016
Markus Geisler et 24 autres auteurs -
CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis – 22/03/2016
Clément Thomas et 8 autres auteurs -
The multifaceted role of autophagy in tumor evasion from immune surveillance – 01/01/2016
Bassam Janji et 12 autres auteurs -
The pH sensibility of actin-bundling LIM proteins is governed by the acidic properties of their C-terminal domain – 12/08/2015
Clément Thomas et 8 autres auteurs -
HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors – 25/06/2015
David G. Fernig et 4 autres auteurs -
Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance – 20/11/2014
Bassam Janji et 9 autres auteurs -
A dynamic interplay between membranes and the cytoskeleton critical for cell development and signaling – 16/07/2014
Clément Thomas et 1 autre auteur -
Correction to Live cell imaging reveals actin-cytoskeleton-induced self-association of the actin-bundling protein WLIM1 [J. Cell Sci. 127, 583-598] – 01/03/2014
Céline Hoffmann et 8 autres auteurs -
Involvement of substance P/neurokinin-1 receptor in the analgesic and anticancer activities of minimally toxic fraction from the traditional Chinese medicine Liu-Shen-Wan in vitro – 01/03/2014
Xiao Jun Li et 4 autres auteurs -
Live cell imaging reveals actin-cytoskeleton-induced self-association of the actin-bundling protein WLIM1 – 01/02/2014
Clément Thomas et 8 autres auteurs -
Human muscle LIM protein dimerizes along the actin cytoskeleton and cross-links actin filaments – 01/01/2014
Clément Thomas et 8 autres auteurs -
A LIM domain protein from tobacco involved in actin-bundling and histone gene transcription – 01/03/2013
Danièle Moes et 11 autres auteurs -
Proteomic profiling of rapid non-genomic and concomitant genomic effects of acute restraint stress on rat thymocytes – 03/04/2012
Claude Muller et 5 autres auteurs -
Arabidopsis actin-depolymerizing factors (ADFs) 1 and 9 display antagonist activities – 23/06/2011
Clément Thomas et 8 autres auteurs -
Arabidopsis LIM proteins – 01/09/2010
Jessica Papuga et 7 autres auteurs -
Mouse natural killer (NK) cells express the nerve growth factor receptor TrkA, which is dynamically regulated – 01/01/2010
Jacques Zimmer et 5 autres auteurs -
Actin bundling in plants – 01/11/2009
Clément Thomas et 6 autres auteurs -
Actin bundling via LIM domains – 01/05/2008
Clément Thomas et 6 autres auteurs -
The LIM domains of WLIM1 define a new class of actin bundling modules – 16/11/2007
Clément Thomas et 8 autres auteurs -
Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity – 30/09/2024
Alessandro Michelucci et 15 autres auteurs -
Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer – 22/07/2024
Mariona Pascal et 18 autres auteurs -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 16/07/2024
Alessandro Michelucci et 20 autres auteurs -
AllergoOncology – 01/01/2024
Aurélie Poli et 29 autres auteurs -
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 02/04/2024
Anna Golebiewska et 24 autres auteurs -
Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques – 01/04/2024
Menno PJ de Winther et 20 autres auteurs -
Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy – 22/02/2024
Feng Q Hefeng et 38 autres auteurs -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 09/02/2024
Alessandro Michelucci et 17 autres auteurs -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 12/12/2023
Anna Golebiewska et 21 autres auteurs -
SUSD2-IL-2 receptor interaction hinders antitumoral CD8+ T-cell activity – 01/01/2023
Ilaria Salvato et 2 autres auteurs -
A SPECT-based method for dynamic imaging of the glymphatic system in rats – 21/02/2023
Maiken Nedergaard et 12 autres auteurs -
PARK7/DJ-1 in microglia – 18/04/2023
Alessandro Michelucci et 3 autres auteurs -
Transcriptional and Chromatin Accessibility Profiling of Neural Stem Cells Differentiating into Astrocytes Reveal Dynamic Signatures Affected under Inflammatory Conditions – 21/03/2023
Alessandro Michelucci et 8 autres auteurs -
Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice – 01/01/2022
Aurélie Poli et 16 autres auteurs -
Correction – 29/11/2022
Aaqib Sohail et 20 autres auteurs -
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline – 21/10/2022
Maiken Nedergaard et 9 autres auteurs -
Adenovirus-mediated delivery of the MHC-II Transactivator CIITA gene induces tumor cell killing in immunocompetent glioblastoma organoids – 05/09/2022
Ilaria Salvato et 9 autres auteurs -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 05/09/2022
Yahaya Abubakar Yabo et 8 autres auteurs -
Modeling immunocompetent tumor microenvironment in glioblastoma patient-derived orthotopic xenografts – 05/09/2022
Pilar Maria Moreno Sanchez et 8 autres auteurs -
AllergoOncology – 01/01/2022
Sophia N. Karagiannis et 30 autres auteurs -
Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency – 01/01/2022
Alessandro Michelucci et 13 autres auteurs -
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism – 01/05/2022
Frank Pessler et 20 autres auteurs -
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson’s disease – 29/01/2022
Manuel Buttini et 24 autres auteurs -
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection – 13/01/2022
Frank Pessler et 20 autres auteurs -
Special issue “microglia heterogeneity and its relevance for translational research” – 16/11/2021
Alessandro Michelucci et 2 autres auteurs -
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation – 09/11/2021
Gerhard Krönke et 25 autres auteurs -
Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice – 01/01/2021
Manuel Buttini et 17 autres auteurs -
Allergic airway inflammation impacts tumor take and delays experimental glioblastoma progression – 01/09/2021
Aurélie Poli et 13 autres auteurs - Tumour-associated microglia/macrophage (TAM) heterogeneity in Glioblastoma – 22/06/2021
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Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors – 18/06/2021
Anaïs Oudin et 16 autres auteurs -
FAM13A regulates KLRG1 expression and interferon gamma production of natural killer cells – 18/05/2021
Ni Zeng et 14 autres auteurs -
Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus – 12/04/2021
Danielle PerezBercoff et 13 autres auteurs -
NF-kappa B and TNF Affect the Astrocytic Differentiation from Neural Stem Cells – 08/04/2021
Cindy Birck et 5 autres auteurs -
Microglia in Health and Disease – 31/03/2021
Alessandro Michelucci et 3 autres auteurs -
Single-cell transcriptomics and In situ morphological analyses reveal microglia heterogeneity across the nigrostriatal pathway – 29/03/2021
Alessandro Michelucci et 8 autres auteurs -
CpG Adjuvant in Allergen-Specific Immunotherapy – 23/02/2021
Markus Ollert et 3 autres auteurs -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
Simone Niclou et 40 autres auteurs -
Interrogating intratumoral transcriptomic heterogeneity and plasticity as resistance mechanisms in glioblastoma – 01/11/2020
Yahaya Abubakar Yabo et 8 autres auteurs -
Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging – 23/09/2020
Lasse Sinkkonen et 16 autres auteurs -
Revealing and harnessing tumour-associated microglia/macrophage heterogeneity in glioblastoma – 01/02/2020
Alessandro Michelucci et 1 autre auteur -
BCL2L15 (BCL2-like 15) – 01/01/2020
Pinelopi I. Artemaki et 2 autres auteurs -
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment – 01/12/2019
Simone Niclou et 21 autres auteurs -
Allergooncology: Delayed glioblastoma progression in a mouse model of allergic airway inflammation – 01/08/2019
Aurélie Poli et 13 autres auteurs -
Region-specific microglial heterogeneity and its potential relevance for Parkinson’s disease – 01/07/2019
Oihane Uriarte Huarte et 8 autres auteurs -
Transcriptional and epigenetic mechanisms underlying astrocyte identity – 01/03/2019
Alessandro Michelucci et 4 autres auteurs -
Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures – 01/11/2018
Alessandro Michelucci et 11 autres auteurs -
Microglia in health and disease: A unique immune cell population – 01/09/2018
Alessandro Michelucci et 2 autres auteurs -
Single-cell transcriptomic analysis of microglia/macrophages in glioblastoma – 01/09/2018
Alessandro Michelucci et 6 autres auteurs -
Microglia in health and disease – 15/08/2018
Alessandro Michelucci et 2 autres auteurs -
Delayed glioblastoma progression by repeated nasal instillations of house dust mite extract in a mouse model – 01/08/2018
Aurélie Poli et 11 autres auteurs -
Human leukocyte antigen class I deficiencies – 01/06/2017
Jacques Zimmer et 2 autres auteurs -
Human CD56bright NK cells – 01/04/2016
Jacques Zimmer et 6 autres auteurs -
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma – 30/09/2014
Cecilie Brekke Rygh et 11 autres auteurs -
Combining NK cells and mAb9.2.27 to combat NG2-dependent and anti-inflammatory signals in glioblastoma – 01/01/2014
Martha Chekenya Enger et 5 autres auteurs -
TAP deficiency is also a cause of bronchiectasis – 01/05/2013
Jacques Zimmer et 4 autres auteurs -
Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level – 01/01/2013
Martha Chekenya Enger et 7 autres auteurs -
Mouse Lung and Spleen Natural Killer Cells Have Phenotypic and Functional Differences, in Part Influenced by Macrophages – 05/12/2012
Tatiana Michel et 7 autres auteurs -
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma – 01/10/2011
Martha Chekenya Enger et 21 autres auteurs -
Increased Th2 cytokine secretion, eosinophilic airway inflammation, and airway hyperresponsiveness in neurturin-deficient mice – 01/06/2011
Tatiana Michel et 7 autres auteurs -
Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescence-activated cell sorting – 01/11/2010
Aurélie Poli et 6 autres auteurs -
NK cells and allergy – 01/01/2010
Tatiana Michel et 4 autres auteurs -
CD56bright natural killer (NK) cells – 01/04/2009
Jacques Zimmer et 5 autres auteurs -
A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions – 01/09/2008
Simone Niclou et 10 autres auteurs -
Control of NK cell functions by CD4+CD25+ regulatory T cells – 01/01/2007
Jacques Zimmer et 6 autres auteurs -
Reduced cytokine-mediated up-regulation of HLA-DR in TAP-deficient fibroblasts – 15/11/2006
Jacques Zimmer et 5 autres auteurs -
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy – 01/01/2024
Bassam Janji et 22 autres auteurs -
Identification of the role of HIF-1α-dependent hypoxia in the regulation of ACKR2 (Atypical Chemokine Receptor 2) expression in cancer – 26/06/2024
Alice Benoit -
Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34 – 11/06/2024
Bassam Janji et 2 autres auteurs -
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden – 28/11/2023
Salem Chouaib et 12 autres auteurs -
CyPep-1 reprograms the tumor microenvironment and enhances the efficacy of immune checkpoint inhibitors – 01/10/2023
Bassam Janji et 7 autres auteurs -
Lighting Up the Fire in the Microenvironment of Cold Tumors – 05/07/2023
Bassam Janji et 4 autres auteurs -
Nanoluciferase-based complementation assays to monitor activation, modulation and signaling of receptor tyrosine kinases (RTKs) – 24/12/2022
Andy Chevigne et 7 autres auteurs -
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo – 23/12/2022
Teresa Ramos et 20 autres auteurs -
Dual blockage of both PD-L1 and CD47 enhances the therapeutic effect of oxaliplatin and FOLFOX in CT-26 mice tumor model – 11/02/2023
Seyed Amir Jalali et 8 autres auteurs -
Basic Concepts of Radiation Biology – 01/01/2023
Ans Baeyens et 30 autres auteurs -
Clinical Radiobiology for Radiation Oncology – 01/01/2023
Peter Sminia et 26 autres auteurs -
Individual Radiation Sensitivity and Biomarkers – 01/01/2023
Elizabeth A. Ainsbury et 19 autres auteurs -
Radiobiology of Accidental, Public, and Occupational Exposures – 01/01/2023
Ruth Wilkins et 17 autres auteurs -
Space Radiobiology – 01/01/2023
Yehoshua Socol et 24 autres auteurs -
A role for EMT in CD73 regulation in breast cancer – 30/11/2022
Bassam Janji et 2 autres auteurs -
The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation – 15/11/2022
Bassam Janji et 8 autres auteurs -
Hypoxia features as potential indicators in prognosis, immunotherapy and drug screening in hepatocellular carcinoma patients – 12/10/2022
Ruize Gao -
Improving neuroblastoma therapy by targeting intratumoral hypoxia and immune checkpoint PD-L1 – 23/09/2022
Delphine Sauvage -
SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC – 09/09/2022
Bassam Janji et 13 autres auteurs -
The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
Bassam Janji et 7 autres auteurs -
Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments – 26/08/2022
Seyed Amir Jalali et 10 autres auteurs -
Radiation dose and schedule influence the abscopal effect in a bilateral murine CT26 tumor model – 10/04/2022
Seyed Amir Jalali et 8 autres auteurs -
The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy – 20/06/2022
Bassam Janji et 1 autre auteur -
VPS34 inhibitor SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist – 15/06/2022
Yasmin Yu et 11 autres auteurs -
The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B – 01/06/2022
Andy Chevigne et 10 autres auteurs -
CMTM6 and CMTM7 – 01/01/2022
Bassam Janji et 4 autres auteurs -
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis – 16/05/2022
Johannes Meiser et 18 autres auteurs -
Editor’s Note – 15/04/2022
Yosra Messai et 21 autres auteurs -
Carbonic Anhydrase IX – 09/03/2022
Najla Santos Pacheco de Campos et 7 autres auteurs -
Nanoluciferase-based methods to monitor activation, modulation and trafficking of atypical chemokine receptors – 18/04/2022
Martyna Szpakowska et 9 autres auteurs -
Impact of epithelial to mesenchymal transition on the regulation of anti-tumour immune response in breast cancer – 16/11/2021
Malina Xiao -
Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model – 01/10/2021
Laura Ochoa-Callejero et 23 autres auteurs -
“Suffocating” tumors by blocking adaptation to hypoxia – 07/09/2021
Bassam Janji et 1 autre auteur -
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy – 01/01/2021
Bassam Janji et 11 autres auteurs -
Mitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer Metastasis – 27/05/2021
Johannes Meiser et 16 autres auteurs -
Epithelial to mesenchymal transition regulates surface pd-l1 via cmtm6 and cmtm7 induction in breast cancer – 09/03/2021
Malina Xiao et 10 autres auteurs -
Cxcl10 is an agonist of the cc family chemokine scavenger receptor ackr2/d6 – 02/03/2021
Martyna Szpakowska et 11 autres auteurs -
Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies – 25/02/2021
Bassam Janji et 7 autres auteurs -
CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis – 01/01/2021
Gwendalyn J. Randolph et 11 autres auteurs -
Selection of tumor-resistant variants following sustained natural killer cell-mediated immune stress – 01/02/2021
Salem Chouaib et 8 autres auteurs -
Specific ACKR2 modulators for use in therapy – 21/01/2021
Bassam Janji et 5 autres auteurs -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) – 01/01/2021
Daniel J. Klionsky et 2928 autres auteurs -
Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34 – 01/11/2020
Bassam Janji et 5 autres auteurs -
Impact du ciblage du domaine de liaison de HIF-1α avec HIF-1b sur le paysage immunitaire du mélanome – 09/10/2020
Audrey Lequeux -
CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems – 05/10/2020
Bernhard Moser et 11 autres auteurs -
The ‘Holy Grail’ in Immuno-Oncology – 01/10/2020
Andreas Schläpfer et 4 autres auteurs -
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway – 02/08/2020
Elisabeth Letellier et 19 autres auteurs -
Checkpoint Inhibitors and Engineered Cells – 29/06/2020
Massimo Giuliani et 1 autre auteur -
The emerging impact of autophagy on the antitumor immune response – 15/05/2020
Meriem Hasmim et 6 autres auteurs -
Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21 – 07/04/2020
Natasha A. Moussouras et 7 autres auteurs -
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy – 01/04/2020
Bassam Janji et 12 autres auteurs -
Assessing autophagy in archived tissue or how to capture autophagic flux from a tissue snapshot – 01/03/2020
Magali Humbert et 17 autres auteurs -
Firing up the cold tumors by targeting Vps34 – 01/01/2020
Bassam Janji et 4 autres auteurs -
The diverse and complex roles of atypical chemokine receptors in cancer – 01/01/2020
Elin Sjöberg et 5 autres auteurs -
Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment – 01/09/2019
Muhammad zaeem NOMAN et 7 autres auteurs -
Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints – 28/08/2019
Bassam Janji et 10 autres auteurs -
The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment – 18/06/2019
Andy Chevigne et 10 autres auteurs -
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide – 01/04/2019
Lars Prestegarden et 19 autres auteurs -
Actin cytoskeleton remodeling drives breast cancer cell escape from natural killer-mediated cytotoxicity – 01/10/2018
Clément Thomas et 13 autres auteurs -
Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer – 28/08/2018
Victoria El Khoury et 13 autres auteurs -
Driving Natural Killer cells toward the melanoma tumor battlefield – 03/08/2018
Bassam Janji et 4 autres auteurs -
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia – 03/08/2018
Marina Wierz et 4 autres auteurs -
Impact of targeting the autophagy related gene Beclin 1 on the immune landscape of melanoma – 09/07/2018
Tsolère Arakelian -
Inhibition of HIF1α-dependent upregulation of phospho-L-Plastin resensitizes multiple myeloma cells to frontline therapy – 01/06/2018
Bassam Janji et 10 autres auteurs -
Targeting autophagy in the tumor microenvironment – 25/04/2018
Bassam Janji et 2 autres auteurs -
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia – 05/04/2018
Marina Wierz et 12 autres auteurs -
CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT – 03/04/2018
Bassam Janji et 10 autres auteurs -
Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield – 03/04/2018
Bassam Janji et 2 autres auteurs -
Driving cytotoxic natural killer cells into melanoma – 01/01/2018
Bassam Janji et 8 autres auteurs -
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner – 31/10/2017
Bassam Janji et 15 autres auteurs -
Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A – 05/09/2017
Simone Niclou et 10 autres auteurs -
The role of autophagy in anti-tumour immune response mediated by Natural Killer cells – 26/06/2017
Takouhie Mgrditchian -
Human CD56dimCD16dimCells As an Individualized Natural Killer Cell Subset – 19/06/2017
Jacques Zimmer et 11 autres auteurs -
Cutting edge – 15/02/2017
Salem Chouaib et 9 autres auteurs -
Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure – 01/02/2017
Salem Chouaib et 8 autres auteurs -
The critical role of hypoxia in tumor-mediated immunosuppression – 01/02/2017
Bassam Janji et 5 autres auteurs -
The immune checkpoint ligand PD-l1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200 – 02/01/2017
Salem Chouaib et 8 autres auteurs -
Activation of NK cells and disruption of PD-L1/PD-1 axis – 01/01/2017
Massimo Giuliani et 2 autres auteurs -
Mesenchymal stromal cells can regulate the immune response in the tumor microenvironment – 01/12/2016
Alessandro Poggi et 1 autre auteur -
Hijacker of the antitumor immune response – 18/11/2016
Bassam Janji et 8 autres auteurs -
Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status – 01/10/2016
Salem Chouaib et 18 autres auteurs -
miR-210 and hypoxic microvesicles – 01/09/2016
Salem Chouaib et 3 autres auteurs -
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer – 02/04/2016
Salem Chouaib et 10 autres auteurs -
CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis – 22/03/2016
Clément Thomas et 8 autres auteurs -
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) – 21/01/2016
Daniel J. Klionsky et 2461 autres auteurs -
Autophagy Activation in the Tumor Microenvironment – 01/01/2016
Bassam Janji et 5 autres auteurs -
Erratum to – 01/01/2016
Daniel J. Klionsky et 2461 autres auteurs -
Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer – 01/01/2016
Victoria El Khoury et 3 autres auteurs -
Role of Autophagy in Tumor Progression and Regression – 01/01/2016
Bassam Janji et 1 autre auteur -
The multifaceted role of autophagy in tumor evasion from immune surveillance – 01/01/2016
Bassam Janji et 12 autres auteurs -
Autophagy regulation of the tumor immunity: An old housekeeper for a new function – 16/12/2015
Tsolère Arakelian et 6 autres auteurs -
miR-181a modulates acute myeloid leukemia susceptibility to natural killer cells – 02/12/2015
Salem Chouaib et 10 autres auteurs -
The selective degradation of synaptic connexin 43 protein by hypoxia-induced autophagy impairs natural killer cell-mediated tumor cell killing – 25/09/2015
Salem Chouaib et 4 autres auteurs -
Tumor-promoting effects of myeloid-derived suppressor cells are potentiated by hypoxia-induced expression of miR-210 – 15/09/2015
Salem Chouaib et 6 autres auteurs -
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts – 27/08/2015
Jérôme Paggetti et 11 autres auteurs -
Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells – 19/06/2015
Nassera Aouali et 8 autres auteurs -
Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression – 23/04/2015
Salem Chouaib et 10 autres auteurs -
Hypoxia – 01/01/2015
Salem Chouaib et 6 autres auteurs -
ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy – 01/12/2014
Salem Chouaib et 21 autres auteurs -
Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance – 20/11/2014
Bassam Janji et 9 autres auteurs -
Autophagy – 01/11/2014
Bassam Janji et 6 autres auteurs -
Hypoxia-induced autophagy in tumor cells: a key target for improving cancer immunotherapy – 14/09/2014
Jérôme Paggetti et 4 autres auteurs -
Bronchial airway gene expression in smokers with lung or head and neck cancer – 01/04/2014
Eric Van Dyck et 15 autres auteurs -
EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction – 01/07/2013
Salem Chouaib et 6 autres auteurs -
Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from t-cell-mediated lysis – 15/04/2013
Salem Chouaib et 16 autres auteurs -
Guidelines for the use and interpretation of assays for monitoring autophagy – 01/04/2012
Daniel J. Klionsky et 1268 autres auteurs -
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression – 15/09/2011
Salem Chouaib et 10 autres auteurs -
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia – 19/04/2011
Etienne Moussay et 10 autres auteurs -
Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response – 01/01/2011
Salem Chouaib et 7 autres auteurs -
Multi-parametric MRI to FMISO PET Synthesis for Hypoxia Prediction in Brain Tumors – 09/10/2024
Daniele Perlo et 8 autres auteurs -
Addressing Artefacts in Anatomical MR Images – 01/05/2024
Selma Boudissa et 4 autres auteurs -
Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
Jonathan Turner et 10 autres auteurs -
Corrigendum to ‘Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model’ [Ultrasound in Med & Biol. 49 (2023) 1082-1090, (S0301562922006664), (10.1016/j.ultrasmedbio.2022.12.006)] – 01/01/2024
Yanrong Zhang et 13 autres auteurs -
Predicting Hypoxia in Brain Tumors from Multiparametric MRI – 25/01/2024
Olivier Keunen et 3 autres auteurs -
Immune cell identity behind the Ktrans mapping of mouse glioblastoma – 21/06/2023
Max Wintermark et 13 autres auteurs -
Large-Scale Deep Learning Medical Image Methodology and Applications using Multiple GPUs – 12/10/2023
Ezhilmathi Krishnasamy et 5 autres auteurs -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model – 01/01/2023
Max Wintermark et 13 autres auteurs -
Author Correction – 26/01/2023
Spyridon Bakas et 278 autres auteurs -
Federated learning enables big data for rare cancer boundary detection – 05/12/2022
Spyridon Bakas et 278 autres auteurs -
Deciphering Human Glioblastoma Invasion Using a Developmental Mature Rat Brain Organoid Model – 15/11/2022
Wenjing Zhou et 30 autres auteurs -
The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
Bassam Janji et 7 autres auteurs -
Federated Learning Enables Big Data for Rare Cancer Boundary Detection – 22/04/2022
Spyridon Bakas et 278 autres auteurs -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia after MRgFUS induced BBB Opening in a Mouse Glioblastoma Model – 15/03/2022
Max Wintermark et 13 autres auteurs -
Exploiting Liver CT scans in Colorectal Carcinoma genomics mutation classification – 01/01/2022
Daniele Perlo et 6 autres auteurs -
Relationship between Metabolically Unhealthy Obesity and Visceral Adipose Tissue in Youth – 01/12/2021
Hanène Samouda et 5 autres auteurs -
Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis – 14/10/2021
Frits Thorsen et 5 autres auteurs -
Inhibition of GBM invasion by the A-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid (AMPA) Glutamate receptor antagonist Perampanel – 09/09/2021
Katharina Sarnow et 3 autres auteurs -
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy – 01/09/2021
Max Wintermark et 13 autres auteurs -
Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors – 18/06/2021
Anaïs Oudin et 16 autres auteurs -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
Simone Niclou et 40 autres auteurs -
Spatially regularized estimation of the tissue homogeneity model parameters in DCE-MRI using proximal minimization – 01/12/2019
Michal Bartos et 5 autres auteurs -
Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood–brain barrier – 01/11/2019
Frits Thorsen et 17 autres auteurs -
THER-11. Peptide mediated permeabilization of the blood-brain-barrier improves drug delivery to brain metastasis – 01/08/2019
Synnøve Nymark Aasen et 17 autres auteurs -
Iterative methods for fast reconstruction of undersampled dynamic contrast-enhanced MRI data – 01/01/2019
Hynek Walner et 6 autres auteurs -
The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency – 08/10/2024
Georges Lacaud et 15 autres auteurs -
Protocol for isolating leukemia-derived extracellular vesicles from the spleen of preclinical models of leukemia using ultracentrifugation – 05/08/2024
Etienne Moussay et 5 autres auteurs -
Assessment of translation rate in leukemic cells and immune cells of the microenvironment by OPP protein synthesis assay – 02/07/2024
Anne Largeot et 4 autres auteurs -
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia – 20/06/2024
Laurent Delva et 16 autres auteurs -
Eμ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia – 18/04/2024
Jérôme Paggetti et 4 autres auteurs -
Characterization of the tumor and its microenvironment in chronic lymphocytic leukemia – 14/05/2024
Iria Fernandez Botana -
Editorial – 08/05/2024
Martin Böttcher et 2 autres auteurs -
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle – 28/02/2024
Johannes Meiser et 20 autres auteurs -
Minimal information for studies of extracellular vesicles (MISEV2023) – 01/02/2024
Joshua A. Welsh et 49 autres auteurs -
Flow cytometry-assisted quantification of cell cycle arrest in cancer cells treated with CDK4/6 inhibitors – 22/08/2023
Giulia Petroni et 4 autres auteurs -
Power out chronic lymphocytic leukemia – 03/08/2023
Jérôme Paggetti et 1 autre auteur -
Molecular determinants of immunogenic cell death elicited by radiation therapy – 01/01/2023
Lorenzo Galluzzi et 3 autres auteurs -
Role of AHR and HIF1α transcription factors in normal and chronic lymphocytic leukemia B lymphocytes – 21/12/2023
Susanne Gonder -
Targeting mRNA translation aberrations – 01/01/2023
Etienne Moussay et 3 autres auteurs -
Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia – 03/11/2023
Jérôme Paggetti et 3 autres auteurs -
Interleukin-27 potentiates CD8+ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia – 22/06/2023
Jérôme Paggetti et 16 autres auteurs -
Immunologically relevant effects of radiation therapy on the tumor microenvironment – 18/05/2023
Lorenzo Galluzzi et 4 autres auteurs -
Formate promotes invasion and metastasis in reliance on lipid metabolism – 30/08/2023
Johannes Meiser et 26 autres auteurs -
Type I interferon and cancer – 01/01/2023
Jitka Fucikova et 6 autres auteurs -
High-dimensional single-cell definition of CLL T cells identifies Galectin-9 as novel immunotherapy target – 30/08/2023
Martina Seiffert et 28 autres auteurs -
Inhibition of MYC translation through targeting of the newly identified PHB-EIF4F complex as therapeutic strategy inchronic lymphocytic leukemia (CLL) – 01/08/2023
Anne Largeot et 32 autres auteurs -
The DNA Damage Response and Inflammation in Cancer – 07/04/2023
Lorenzo Galluzzi et 5 autres auteurs -
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL – 01/01/2023
Anne Largeot et 32 autres auteurs -
SOHO State of the Art Updates and Next Questions | Infections in Chronic Lymphocytic Leukemia Patients – 10/02/2023
Carsten U Niemann et 2 autres auteurs -
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells – 01/01/2023
Johannes Meiser et 33 autres auteurs -
The protective role of the microenvironment in hairy cell leukemia treatment – 08/03/2023
Pablo Elias Morande et 5 autres auteurs -
PKM2 diverts glycolytic flux in dependence on formate overflow – 23/01/2023
Johannes Meiser et 17 autres auteurs -
Role of AHR, HIF-1α and IL-27 In T-cell-mediated immunity in chronic lymphocytic leukemia – 09/01/2023
Giulia Pagano -
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses – 15/09/2022
Jérôme Paggetti et 16 autres auteurs -
T cell landscape definition by multi-omics identifies Galectin-9 as novel immunotherapy target in chronic lymphocytic leukemia – 16/12/2022
Martina Seiffert et 26 autres auteurs -
Single-Cell Omics Analyses Identify the TIM-3 Ligand Galectin-9 As Novel Immunotherapy Target for Chronic Lymphocytic Leukemia – 15/11/2022
Laura Llaó Cid et 15 autres auteurs -
Small extracellular vesicles – 27/09/2022
Ernesto Gargiulo et 3 autres auteurs -
The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
Bassam Janji et 7 autres auteurs -
Natural killer cells and bone marrow mesenchymal stem cells – 28/07/2022
Jérôme Paggetti et 2 autres auteurs -
Targeting translation by disrupting the newly identified prohibitin-eif4f complex as a novel therapeutic strategy in chronic lymphocytic leukemia – 01/06/2022
Anne Largeot et 9 autres auteurs -
Editor’s Note – 15/04/2022
Yosra Messai et 21 autres auteurs -
PRMT2 : un facteur épigénétique anti-inflammatoire impliqué dans l’agressivité des leucémies aiguës myéloblastiques – 01/03/2022
C. Sauter et 14 autres auteurs -
A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia – 28/02/2022
Agnieszka Goral et 17 autres auteurs -
Editorial – 03/02/2022
Martina Seiffert et 2 autres auteurs -
Editorial – 17/01/2022
Etienne Moussay et 2 autres auteurs -
Editorial – 15/12/2021
Jérôme Paggetti et 2 autres auteurs -
Impact of small extracellular vesicles on anti-tumor immunity in chronic lymphocytic leukemia in vivo – 17/11/2021
Ernesto Gargiulo -
The tumor microenvironment-dependent transcription factors ahr and hif-1α are dispensable for leukemogenesis in the eµ-tcl1 mouse model of chronic lymphocytic leukemia – 08/09/2021
Susanne Gonder et 7 autres auteurs -
In Vitro Sensitivity to Venetoclax and Microenvironment Protection in Hairy Cell Leukemia – 26/07/2021
Pablo Elias Morande et 14 autres auteurs -
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms – 22/07/2021
Pablo Oppezzo et 19 autres auteurs -
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy – 01/01/2021
Bassam Janji et 11 autres auteurs -
Immunomodulatory effects of different intravenous immunoglobulin preparations in chronic lymphocytic leukemia – 21/06/2021
Mercedes Borge et 8 autres auteurs -
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling – 24/05/2021
Clément Thomas et 11 autres auteurs -
Method for the Analysis of the Tumor Microenvironment by Mass Cytometry – 20/10/2020
Susanne Gonder et 8 autres auteurs -
Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies – 29/09/2020
Ernesto Gargiulo et 4 autres auteurs -
Characterisation of the tumour microenvironment in chronic lymphocytic leukemia by mass cytometry: implications for immunotherapy – 14/09/2020
Marina Wierz -
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway – 02/08/2020
Elisabeth Letellier et 19 autres auteurs -
Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasion from cytotoxic lymphocytes – 01/01/2020
Andrea Michela Biolato et 6 autres auteurs -
Eomes and IL-10 Regulate Anti-Tumor Activity of T Cells in Chronic Lymphocytic Leukemia – 13/11/2019
Laura Llao Cid et 10 autres auteurs -
Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints – 28/08/2019
Bassam Janji et 10 autres auteurs -
Hematological malignancy-derived small extracellular vesicles and tumor microenvironment – 27/05/2019
Ernesto Gargiulo et 2 autres auteurs -
The B-side of cancer immunity – 13/05/2019
Anne Largeot et 4 autres auteurs -
HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells – 11/04/2019
Carmen Garrido et 18 autres auteurs -
Chronic Lymphocytic Leukaemia-derived exosomes: A potential strategy for immune escape – 01/01/2019
Ernesto Gargiulo -
Chronic Lymphocytic Leukaemia-derived small extracellular vesicles: A potential strategy for immune escape – 01/01/2019
Ernesto Gargiulo -
Purification of leukemia-derived exosomes to study microenvironment modulation – 01/01/2019
Jérôme Paggetti et 5 autres auteurs -
Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis – 01/10/2018
Azim Dehghani Amirabad et 6 autres auteurs -
Driving Natural Killer cells toward the melanoma tumor battlefield – 03/08/2018
Bassam Janji et 4 autres auteurs -
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia – 03/08/2018
Marina Wierz et 4 autres auteurs -
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia – 05/04/2018
Marina Wierz et 12 autres auteurs -
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model – 23/03/2018
Marina Wierz et 7 autres auteurs -
Exosome proteins and RNAas biomarkers of hematologic malignancies development and progression – 01/01/2018
Ernesto Gargiulo -
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner – 31/10/2017
Bassam Janji et 15 autres auteurs -
Tumor-derived exosomes modulate PD-L1 expression in monocytes – 01/01/2017
Martina Seiffert et 20 autres auteurs -
Hijacker of the antitumor immune response – 18/11/2016
Bassam Janji et 8 autres auteurs -
A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells – 01/07/2016
Sandrine Medves et 15 autres auteurs -
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer – 02/04/2016
Salem Chouaib et 10 autres auteurs -
BCR engagement in CLL – 28/01/2016
Jérôme Paggetti et 1 autre auteur -
Assessing cellular and circulating miRNA recovery – 20/01/2016
Victoria El Khoury et 4 autres auteurs -
Autophagy Activation in the Tumor Microenvironment – 01/01/2016
Bassam Janji et 5 autres auteurs -
The multifaceted role of autophagy in tumor evasion from immune surveillance – 01/01/2016
Bassam Janji et 12 autres auteurs -
Autophagy regulation of the tumor immunity: An old housekeeper for a new function – 16/12/2015
Tsolère Arakelian et 6 autres auteurs -
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts – 27/08/2015
Jérôme Paggetti et 11 autres auteurs -
ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy – 01/12/2014
Salem Chouaib et 21 autres auteurs -
Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance – 20/11/2014
Bassam Janji et 9 autres auteurs -
Hypoxia-induced autophagy in tumor cells: a key target for improving cancer immunotherapy – 14/09/2014
Jérôme Paggetti et 4 autres auteurs -
Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia – 01/08/2014
Victoria El Khoury et 7 autres auteurs -
Bronchial airway gene expression in smokers with lung or head and neck cancer – 01/04/2014
Eric Van Dyck et 15 autres auteurs -
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression – 15/09/2011
Salem Chouaib et 10 autres auteurs -
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia – 19/04/2011
Etienne Moussay et 10 autres auteurs -
Peroxisome proliferator-activated receptor γ agonists potentiate the cytotoxic effect of valproic acid in multiple myeloma cells – 01/12/2009
Guy Berchem et 10 autres auteurs -
Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma – 30/09/2024
Giulia D’Uonnolo et 10 autres auteurs -
Digital voice-based biomarker for monitoring respiratory quality of life – 01/10/2024
Vladimir Despotovic et 6 autres auteurs -
Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity – 30/09/2024
Alessandro Michelucci et 15 autres auteurs -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 16/07/2024
Alessandro Michelucci et 20 autres auteurs -
consICA – 13/07/2024
Petr Nazarov et 4 autres auteurs -
AllergoOncology – 01/01/2024
Aurélie Poli et 29 autres auteurs -
Most accurate mutations in SARS-CoV-2 genomes identified in Uzbek patients show novel amino acid changes – 31/05/2024
Ibrokhim Y. Abdurakhmonov et 10 autres auteurs -
Enhancing the opportunities for cholangiocarcinoma precision therapy – 16/01/2024
Javier Vaquero et 2 autres auteurs -
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 02/04/2024
Anna Golebiewska et 24 autres auteurs -
Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells – 25/03/2024
Madhuri S. Salker et 13 autres auteurs -
Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning – 15/03/2024
Vladimir Despotovic et 8 autres auteurs -
Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
Jonathan Turner et 10 autres auteurs -
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 09/02/2024
Alessandro Michelucci et 17 autres auteurs -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 12/12/2023
Anna Golebiewska et 21 autres auteurs -
Inhibition of MIR-146A-5P decreases progression of melanoma brain metastasis via notch pathway dysregulation in astrocytes – 10/11/2023
E. K. Rigg et 19 autres auteurs -
Targeting the dna damage response in glioblastoma propagating cells: from molecular mechanisms to precision medicine – 10/11/2023
Alexandros Pailas et 9 autres auteurs -
Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes – 01/10/2023
Emma Rigg et 19 autres auteurs -
Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study – 29/09/2023
Vladimir Despotovic et 8 autres auteurs -
Integrative omics analysis of IDH1 mutant glioma patients reveals alterations in butyrate metabolism – 08/09/2023
Sabrina Fritah et 9 autres auteurs -
Stability of stochastic dynamic systems of a random structure with Markov switching in the presence of concentration points – 16/08/2023
Petr Nazarov et 3 autres auteurs -
Inhibition of MYC translation through targeting of the newly identified PHB-EIF4F complex as therapeutic strategy inchronic lymphocytic leukemia (CLL) – 01/08/2023
Anne Largeot et 32 autres auteurs -
Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response – 27/06/2023
Stephanie Kreis et 11 autres auteurs -
Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing – 01/07/2023
Ibrokhim Abdurakhmonov et 9 autres auteurs -
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL – 01/01/2023
Anne Largeot et 32 autres auteurs -
Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas – 06/06/2023
Eric Van Dyck et 4 autres auteurs -
Stability of stochastic dynamic systems of a random structure with Markov switchings in the presence of concentration points – 19/05/2023
Taras Lukashiv et 3 autres auteurs -
Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking – 22/03/2023
Christoph Plass et 19 autres auteurs -
Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice – 01/01/2022
Aurélie Poli et 16 autres auteurs -
Stabilization of Stochastic Dynamical Systems of a Random Structure with Markov Switches and Poisson Perturbations – 01/02/2023
Petr Nazarov et 4 autres auteurs -
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses – 15/09/2022
Jérôme Paggetti et 16 autres auteurs -
Stabilization of stochastic dynamical systems of a random structure with Markov switches and Poisson perturbations – 15/12/2022
Taras Lukashiv et 4 autres auteurs -
Vocal biomarker predicts fatigue in people with COVID-19 – 22/11/2022
Guy Fagherazzi et 7 autres auteurs -
Deciphering Human Glioblastoma Invasion Using a Developmental Mature Rat Brain Organoid Model – 15/11/2022
Wenjing Zhou et 30 autres auteurs -
Discovery and Analytical Validation of a Vocal Biomarker to Monitor Anosmia and Ageusia in Patients with COVID-19 – 07/09/2022
Guy Fagherazzi et 6 autres auteurs -
A voice-based biomarker for monitoring symptom resolution in adults with COVID-19 – 20/10/2022
Guy Fagherazzi et 8 autres auteurs -
Extracellular vesicle derived-MIR-146A increases melanoma brain metastasis progression via notch signalling pathway dysregulation – 05/09/2022
E. K. Rigg et 16 autres auteurs -
Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 05/09/2022
Yahaya Abubakar Yabo et 8 autres auteurs -
Ten quick tips for biomarker discovery and validation analyses using machine learning – 11/08/2022
Enrico Glaab et 7 autres auteurs -
Long COVID Symptomatology After 12 Months and Its Impact on Quality of Life According to Initial Coronavirus Disease 2019 Disease Severity – 05/08/2022
Guy Fagherazzi et 8 autres auteurs -
Linear system identifiability from single-cell data – 01/07/2022
Jorge Goncalves et 2 autres auteurs -
Model-based assessment of COVID-19 epidemic dynamics by wastewater analysis – 25/06/2022
Atte Aalto et 7 autres auteurs -
BIODICA – 06/04/2022
Nicolas Captier et 8 autres auteurs -
Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells – 11/05/2022
Antonio Marchini et 8 autres auteurs -
ORFhunteR – 01/05/2022
Vasily V. Grinev et 4 autres auteurs -
Designing of learning content for a university online course – 01/04/2022
V. M. Lutkovski et 1 autre auteur -
A DNA Damage Repair Signature in Pediatric High-Grade Gliomas: XRCC1 and PARP1, Key Biomarkers – 01/11/2021
N. Entz-Werle et 6 autres auteurs -
In silico approach for validating and unveiling new applications for prognostic biomarkers of endometrial cancer – 09/10/2021
Eva Coll de la Rubia et 7 autres auteurs -
DECONbench – 02/10/2021
Clémentine Decamps et 50 autres auteurs -
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase – 27/09/2021
Eric Van Dyck et 16 autres auteurs -
Allergic airway inflammation impacts tumor take and delays experimental glioblastoma progression – 01/09/2021
Aurélie Poli et 13 autres auteurs -
Phenotypic heterogeneity and plasticity as resistance mechanisms in glioblastoma – 01/09/2021
Yahaya Abubakar Yabo et 5 autres auteurs -
PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα – 25/06/2021
Achim Leutz et 10 autres auteurs -
A DNA repair and cell cycle gene expression signature in pediatric high‐grade gliomas – 07/05/2021
Natacha Entz‐werlé et 13 autres auteurs -
Integrative approaches for analysis of mRNA and microRNA high-throughput data – 01/01/2021
Petr Nazarov et 1 autre auteur -
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion – 01/12/2020
Simone Niclou et 18 autres auteurs -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
Simone Niclou et 40 autres auteurs -
Systematic Transcriptional Profiling of Responses to STAT1- and STAT3-Activating Cytokines in Different Cancer Types – 06/11/2020
Stephanie Kreis et 9 autres auteurs -
Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz – 01/10/2020
Pavlo Lutsik et 10 autres auteurs -
Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics – 26/08/2020
Mi Yang et 50 autres auteurs -
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway – 02/08/2020
Elisabeth Letellier et 19 autres auteurs -
Deconvolution of “big data” in cancer genomics: from pancancer level to single cells – 09/07/2020
M. Chepeleva et 5 autres auteurs -
Independent component analysis of cancer transcriptomes: optimization of parameters and improvement of interpretability – 09/07/2020
M. Chepeleva et 3 autres auteurs -
Identification of a blood-based protein biomarker panel for lung cancer detection – 01/06/2020
Victoria El Khoury et 22 autres auteurs -
Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software – 13/01/2020
Magali Richard et 44 autres auteurs -
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment – 01/12/2019
Simone Niclou et 21 autres auteurs -
Genome-wide shRNA screen identifies candidate genes driving glioblastoma invasion – 01/11/2019
Anne Schuster et 9 autres auteurs -
Intrinsic tumor plasticity in glioblastoma allows for recreation of stem like-states and efficient tumor cell adaveveion to new microenvironments – 01/11/2019
Anna Golebiewska et 12 autres auteurs -
Connecting histopathology imaging and proteomics in kidney cancer through machine learning – 01/10/2019
Francisco Azuaje et 3 autres auteurs -
Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients – 18/09/2019
Petr Nazarov et 8 autres auteurs -
Power-law behavior of the alternative splicing of exons in human transcriptome – 02/09/2019
Vasily V. Grinev et 2 autres auteurs -
Independent component analysis for unraveling the complexity of cancer omics datasets – 01/09/2019
Andrei Zinovyev et 11 autres auteurs -
Genome-wide shRNA screen identifies candidate genes driving glioblastoma invasion – 03/08/2019
Anne Schuster et 9 autres auteurs -
A 3D brain organoid coculture system delineates the invasive cell components in glioblastoma – 01/08/2019
Wenjing Zhou et 11 autres auteurs -
Intrinsic tumor plasticity in glioblastoma allows for recreation of stem like-states and efficient tumor cell adaptation to new microenvironments – 01/08/2019
Anna Golebiewska et 12 autres auteurs -
Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity – 28/05/2019
Elisabeth Letellier et 11 autres auteurs -
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses – 05/03/2019
Francisco Azuaje et 8 autres auteurs -
RNAi/CRISPR Screens – 01/01/2019
Anne Schuster et 6 autres auteurs -
A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma – 01/01/2019
Eric Van Dyck et 11 autres auteurs -
Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer – 28/08/2018
Victoria El Khoury et 13 autres auteurs -
Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach – 07/06/2018
Francisco Azuaje et 7 autres auteurs -
Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways – 01/12/2017
Simone Niclou et 16 autres auteurs -
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish – 31/05/2016
Francisco Azuaje et 17 autres auteurs -
What do we learn from spheroid culture systems? Insights from tumorspheres derived from primary colon cancer tissue – 08/01/2016
Komal Qureshi-Baig et 6 autres auteurs -
Whole transcriptome microarrays identify long non-coding RNAs associated with cardiac hypertrophy – 01/09/2015
Yvan Devaux et 9 autres auteurs -
Verification of the biomarker candidates for non-small-cell lung cancer using a targeted proteomics approach – 06/03/2015
Bruno Domon et 7 autres auteurs -
Transcriptional response to cardiac injury in the zebrafish – 03/10/2014
Francisco Azuaje et 9 autres auteurs -
Technical considerations for large-scale parallel reaction monitoring analysis – 04/04/2014
Bruno Domon et 3 autres auteurs -
Correction – 18/04/2013
Zsuzsa Rakosy et 10 autres auteurs -
Use of circulating microRNAs to diagnose acute myocardial infarction – 01/03/2012
Daniel Wagner et 10 autres auteurs -
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia – 19/04/2011
Etienne Moussay et 10 autres auteurs -
Multi-parametric MRI to FMISO PET Synthesis for Hypoxia Prediction in Brain Tumors – 09/10/2024
Daniele Perlo et 8 autres auteurs -
Addressing Artefacts in Anatomical MR Images – 01/05/2024
Selma Boudissa et 4 autres auteurs -
Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
Jonathan Turner et 10 autres auteurs -
Corrigendum to ‘Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model’ [Ultrasound in Med & Biol. 49 (2023) 1082-1090, (S0301562922006664), (10.1016/j.ultrasmedbio.2022.12.006)] – 01/01/2024
Yanrong Zhang et 13 autres auteurs -
Predicting Hypoxia in Brain Tumors from Multiparametric MRI – 25/01/2024
Olivier Keunen et 3 autres auteurs -
Immune cell identity behind the Ktrans mapping of mouse glioblastoma – 21/06/2023
Max Wintermark et 13 autres auteurs -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model – 01/01/2023
Max Wintermark et 13 autres auteurs -
Author Correction – 26/01/2023
Spyridon Bakas et 278 autres auteurs -
Federated learning enables big data for rare cancer boundary detection – 05/12/2022
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Deciphering Human Glioblastoma Invasion Using a Developmental Mature Rat Brain Organoid Model – 15/11/2022
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The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
Bassam Janji et 7 autres auteurs -
Federated Learning Enables Big Data for Rare Cancer Boundary Detection – 22/04/2022
Spyridon Bakas et 278 autres auteurs -
Molecular Identity Changes of Tumor-Associated Macrophages and Microglia after MRgFUS induced BBB Opening in a Mouse Glioblastoma Model – 15/03/2022
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Relationship between Metabolically Unhealthy Obesity and Visceral Adipose Tissue in Youth – 01/12/2021
Hanène Samouda et 5 autres auteurs -
Inhibition of GBM invasion by the A-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid (AMPA) Glutamate receptor antagonist Perampanel – 09/09/2021
Katharina Sarnow et 3 autres auteurs -
Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy – 01/09/2021
Max Wintermark et 13 autres auteurs -
Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors – 18/06/2021
Anaïs Oudin et 16 autres auteurs -
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
Simone Niclou et 40 autres auteurs -
Is there a prominent role for MR spectroscopy in the clinical management of brain tumors? – 01/07/2020
Simone Niclou et 1 autre auteur -
Spatially regularized estimation of the tissue homogeneity model parameters in DCE-MRI using proximal minimization – 01/12/2019
Michal Bartos et 5 autres auteurs -
Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood–brain barrier – 01/11/2019
Frits Thorsen et 17 autres auteurs -
THER-11. Peptide mediated permeabilization of the blood-brain-barrier improves drug delivery to brain metastasis – 01/08/2019
Synnøve Nymark Aasen et 17 autres auteurs -
Improved treatment of melanoma brain metastasis using a synthetic peptide – 01/11/2018
Synnove Nymark Aasen et 14 autres auteurs -
Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma – 01/10/2018
Olivier Keunen et 9 autres auteurs -
EGFL7 enhances surface expression of integrin α 5 β 1 to promote angiogenesis in malignant brain tumors – 01/09/2018
Mirko H.H. Schmidt et 17 autres auteurs -
The good drug, the bad barrier and the handy peptide: Improved treatment of experimental melanoma brain metastases using a synthetic peptide – 01/07/2018
Synnove Nymark Aasen et 10 autres auteurs -
Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways – 01/12/2017
Simone Niclou et 16 autres auteurs -
Subtraction of subcutaneous fat to improve the prediction of visceral adiposity – 01/08/2017
Hanène Samouda et 9 autres auteurs -
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation – 01/12/2016
Hrvoje Miletic et 29 autres auteurs -
Cardiometabolic risk – 01/06/2016
Hanène Samouda et 11 autres auteurs -
Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma – 31/05/2016
Simone Niclou et 18 autres auteurs -
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma – 27/11/2015
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Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas – 17/01/2015
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Actualités associées
CANBIO
CANBIO est une unité de formation et de recherche doctorale (DTU) qui s’intéresse au problème clinique de la progression et de la récurrence des tumeurs. Les candidats au doctorat au sein de CANBIO sont engagés dans un effort collaboratif et interdisciplinaire afin de fournir des informations nouvelles sur les mécanismes d’échappement des tumeurs, le suivi des maladies et l’analyse de données à grande échelle dans les cancers hautement malins.
i2TRON
TTM joue un rôle de premier plan dans la coordination d’i2TRON, une unité de formation doctorale (UDF) axée sur le développement de la nouvelle génération de scientifiques translationnels, capables de transformer les observations faites en laboratoire, en milieu clinique ou dans la communauté en interventions qui améliorent la santé des individus grâce à des diagnostics ou des traitements innovants.
Visitez la page web correspondante pour plus d’informations :
Postes à pourvoir
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Laboratory Technician (JA/LT1124/AAP/TCI)
Department of Cancer Research – Translational Cancer Immunogenomics
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Post-Doctoral Fellow in Brain Tumor Immunology (JA/PD1124/AP/NIG)
Department of Cancer Research – Neuro-Immunology Group