Translational Medicine Operations Hub (TMOH)

TMOH offers the infrastructure to support translational medicine research.

activities

The Translational Medicine Operations Hub (TMOH) ensures full research support from the operational planning of the study to their execution and closure via the collection, processing, storage and analysis of high-quality biological samples and structured clinical data.

The Translational Medicine Operations Hub (TMOH) includes the operational units of the LIH (CPMO, CIEC, CCMS, IBBL) and its collaborative platforms (LCTR, DMSP, LuxGen, RPP) to integrate and optimise their accessibility, workflows and project/portfolio oversight.

The TMOH provides the infrastructure to intra-institutional research, as well as transversal translational projects of “Research Luxembourg” and collaborations with external partners. These include publicly funded Research Projects like LITMUS, NCER-PD and CLINNOVA, as well as collaborations with industry partners. The central contact point of TMOH is the CPMO, which will guide researchers and their projects through the TMOH processes, as well as plan and track project execution.

As part of its mission, the TMOH hopes to improve patients’ lives by providing Operational Excellence:

  • Single Point of contact regarding Research Services for internal & external stakeholders
  • Seamless workflow and high-quality project execution
  • Consultation for projects regarding project design, operations, regulatory aspects, among others
  • Inbuilt collaboration (clear processes, interfaces, R&R) and exchange of resources (technologies, SME)
  • Transparent information/communication E2E (TMOH, LIH and beyond…)
  • Continuous development – of methods, technology, science, quality, and processes, among others

Director of department 

The Department was established in July 2021, and Dr Hermann Thien was appointed as its Director. Hermann gained over 20 years of experience in the Pharmaceutical and Diagnostics Industry before joining LIH in March 2021.

Hermann
Thien

Projects & clinical trials

Neuro-Immunology Group Cancer
Prognostic Impact of Monocyte subsets in Patients with Glioblastoma
Human Biomonitoring Research Unit Immunological Disorders
New strategies for assessing exposure to endocrine disruptor’s rapid elimination by analysis of non-invasive biological samples
Experimental and Molecular Immunology Immune Endocrine and Epigenetics
COvid-19 National survey for assessing Viral spread by Non-affected Carriers
Cancer
Personal Functional Profiling
Parkinson’s Disease
Assessing the Pharmacokinetics, Safety, Tolerability and Efficacy of Continuous Oral Levodopa via the DopaFuse® Delivery System in Parkinson’s Disease Patients
Immunological Disorders Covid-19 – Infectious Diseases
Improved flucytosine formulation for the treatment of meningitis in advanced HIV disease
Covid-19 – Infectious Diseases
Development and hosting of central database platform for collection of safety data in the scope of active TB drug-safety monitoring
Covid-19 – Infectious Diseases
Peptide / protein /single-cell map of the renin-angiotensin system in Covid-19
Covid-19 – Infectious Diseases
A multilateral initiative to foster the clinical development of effective malaria vaccine candidates in Africa
Covid-19 – Infectious Diseases
A randomised parallel-group pharmacokinetic study to evaluate the bioequivalence of different formulations of moxidectin in adults
Covid-19 – Infectious Diseases
Moxidectin for accelerating onchocerciasis elimination: A paediatric dose-finding study, a phase 3b trialc omparing efficacy and safety of annual and biannual moxidectin or ivermectin treatment and mathematical modelling of moxidectin and ivermectin based elimination strategies to support country policy decision
Deep Digital Phenotyping Research Unit Covid-19 – Infectious Diseases
Unravelling Data for Rapid Evidence-Based Response to COVID-19
Covid-19 – Infectious Diseases
Data management of global aDSM database in the scope of active TB drug-safety monitoring
Competence Centre for Methodology and Statistics
Data Analysis of Response to Anthelmintic Treatment
Competence Centre for Methodology and Statistics
Development of a Good Data Management Practices (GDMP) training course
National Cytometry Platform
Optimized Multicolor Immunofluorescence Panel (OMIP) Database
Digital Medicine Digital Health
QTrobot – a digital therapeutic device for in-home therapy of children with autism
Immunological Disorders Covid-19 – Infectious Diseases
European Clinical Research Infrastructure Network
National Cytometry Platform Multiomics Data Science
IPerGlio: Improving personalized glioblastoma care by intertwined immunomics and artificial intelligence approaches
Covid-19 – Infectious Diseases
European platform for neurodegenerative disorders
Parkinson’s Disease
Molecular, Organellar and Cellular Quality Control in Parkinson’s disease and other Neurodegenerative Diseases
Global Platform for the Prevention of Autoimmune Diabetes
ExpoBiome – Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease
Cancer
PERSONAL FUNCTIONAL PROFILING FOR DRUG DISCOVERY IN MELANOMA AND COLORECTAL CANCER
Clinical and Epidemiological Investigation Center (CIEC)
Validation of the Point Prevalence Survey of healthcare-associated infections and antimicrobial use in acute care hospitals in Luxembourg
Covid-19 – Infectious Diseases
CONVINCE-ORCHESTRA
Cancer
Data solutions based on a basket prospective trial with pembrolizumab and Vorinostat in patients with late stage squamous cell carcinoma
Clinical Research
Safety and efficacy of Novadip 3D osteogenic implants
Clinical Research
Safety and efficacy of Novadip autologous 3D osteogenic implant in the treatment of recalcitrant limb nonunion
Integrated Biobank of Luxembourg (IBBL)
Development of a novel microbiota-based therapy for the prevention of type 2 diabetes mellitus
Multiomics Data Science
Consolidating the capacities of EATRIS-ERIC for Personalised Medicine
National Cytometry Platform Cancer
CompOnco: Common targetable biomarkers in canine hemangiosarcoma and human angiosarcoma
Multiomics Data Science Cancer
Pre-operative methylation-based brain tumor classification
Multiomics Data Science
Consolidating the capacities of EATRIS-ERIC for Personalised Medicine
Entretien pharmaceutique (EP) pour patients asthmatiques
Covid-19 – Infectious Diseases
ORCHESTRA
Parkinson’s Disease
NCER-PD
Recruiting
Covid-19 – Infectious Diseases
CON-VINCE
Molecular and Translational Allergology
Exploring early immune mechanisms of food allergic reactions in humans to develop markers and treatment targets
Clinical and Epidemiological Investigation Center (CIEC) Competence Centre for Methodology and Statistics
Analysis and processing of variations not requiring assessment (VNRA) relating to veterinary medicinal products by the LIH on behalf of the DPM
Fluar-Clinical
Cancer
IMMUcan – Integrated IMMUnoprofiling of large adaptive CANcer patients cohorts
Cancer
taRgeted thErapy for adVanced colorEctal canceR paTients
The Detectives of Epidemiology
Molecular and Translational Allergology Immunological Disorders
APSIS: Paving the way for novel personalized medicine approaches to diagnose and cure food allergies
View all projects on our research portal

Featured team members

  • Francisco Javier
    Alves Ferreira     Visiting Researcher
  • Wim
    Ammerlaan     Head of Biorefinery
  • Dominique
    Brault     eClinical Project Manager
  • Olfa
    Chouchane-Mlik     Visiting Researcher
  • Adrian
    Cuevas Bourdier     Visiting Researcher
  • Fatima
    Descles     Pathology Assistant
  • Katrin
    Frauenknecht     Visiting Researcher
  • Estelle
    Henry     Biorefinery Technician
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