Tumor Stroma Interactions
The Tumor Stroma Interactions group studies the mechanisms leading to leukemia progression.
Activities
The Tumor Stroma Interactions research group is a dynamic and multinational team studying the mechanisms leading to leukemia progression with the goal to identify new prognostic markers and therapeutic targets.
Some of the group’s research projects include:
- Exosomes in B-cell malignancies – to identify potential biomarkers in exosomes derived from murine preclinical models and cells of patients affected by hematologic malignancies and to test their influence on cells from the microenvironment.
- Tumor immunology – to identify new cellular populations which could be used as biomarkers for the response to treatment and potential new therapeutic targets.
- New therapeutic targets in CLL – to investigate the therapeutic efficacy and mode of action of new molecules inhibiting translation machinery and prohibitins in chronic lymphocytic leukemia (CLL), both in patient cells and in a murine model.
Collaborations
Projects & clinical trials
Featured team members
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Rafael
Barros Laboratory Assistant -
Michaela
Bauer Postdoctoral Fellow -
Coralie
Borne Postdoctoral Fellow -
Chloé
Duculty PhD Student -
Iria
Fernandez Botana Postdoctoral Fellow -
Ozgu
Gumustekin PhD Student -
Maxmilan
Jeyakumar Postdoctoral Fellow -
Vanessa
Klapp PhD Student
Scientific publications
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The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency – 08/10/2024
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Protocol for isolating leukemia-derived extracellular vesicles from the spleen of preclinical models of leukemia using ultracentrifugation – 05/08/2024
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Assessment of translation rate in leukemic cells and immune cells of the microenvironment by OPP protein synthesis assay – 02/07/2024
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Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia – 20/06/2024
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Eμ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia – 18/04/2024
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