In vivo imaging
We provide preclinical imaging & advanced images analysis services to the Luxembourg Research Community and beyond.
Services
The mission of the In vivo Imaging Platform (IIP) is to provide preclinical in vivo imaging services to the scientific community. Different equipments are available, including a 3T MRI system, an Optical Imager and Analysis Workstations. We also provide access to a PET/CT system through a partnership with a long time collaborator.
The MRI and Optical Imager are located in the Specific Pathogen Free Animal Facility of the Luxembourg Institute of Health (LIH) in Luxembourg. Equipments needed for anesthesia, temperature control and physiological parameters monitoring are available at the facility.
The platform is commonly used today to validate in vitro experimental findings in preclinical models and to qualify promising new drugs or treatments paradigms before they are considered for clinical trials. Applications range from Oncology to Neuro-degenerative and Cardio-vascular diseases. All studies are subject to prior approval by the local Ethical Committee.
We provide assistance in setting up projects, optimizing imaging protocols & analysing data to those who need it. Experienced users can also use the platform autonomously provided they have the necessary accreditations and can demonstrate sufficient expertise in animal handling & imaging experimentation.
Technologies
- Magnetic Resonance Imaging
- Optical Imaging
- Positron Emission Tomography
- Images Analysis
Keunen
Featured team members
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Georgia
Kanli Research Engineer -
Olivier
Keunen Group Leader
Scientific publications
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Quantitative pre-clinical imaging of hypoxia and vascularity using MRI and PET – 01/01/2024
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Simultaneous Image Quality Improvement and Artefacts Correction in Accelerated MRI – 23/10/2024
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Multi-parametric MRI to FMISO PET Synthesis for Hypoxia Prediction in Brain Tumors – 09/10/2024
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Addressing Artefacts in Anatomical MR Images – 01/05/2024
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Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
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Corrigendum to ‘Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model’ [Ultrasound in Med & Biol. 49 (2023) 1082-1090, (S0301562922006664), (10.1016/j.ultrasmedbio.2022.12.006)] – 01/01/2024
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Predicting Hypoxia in Brain Tumors from Multiparametric MRI – 25/01/2024
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Immune cell identity behind the Ktrans mapping of mouse glioblastoma – 21/06/2023
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Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model – 01/01/2023
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Author Correction – 26/01/2023
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