Publications » Luxembourg Institute of Health

PRECISION-PDX

Advancing personalised cancer treatment for patients with brain tumours. Help change the future of Brain Cancer treatment!

Scientific outputs

Main publications describing the PRECISION-PDX patient avatar collection:

Golebiewska A*, Hau A-C*, Oudin A*, Stieber D, Yabo Y A, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov P V, Azuaje F, de Falco A, Flies B, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Noushmehr H, Kwon Y-J, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R and Niclou SP; Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica, Oct 2020. | Link

Oudin A, Baus V, Barthelemy V, Fabian C, Klein E, Dieterle M, Wantz M, Hau AC, Dording C, Bernard A, Michelucci A, Yabo YA, Kanli G, Keunen O, Bjerkvig R, Niclou SP, Golebiewska A. Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors. STAR Protoc. 2021 May 12;2(2):100534. doi: 10.1016/j.xpro.2021.100534 | Link

Yabo YA, Moreno-Sanchez PM, Pires-Afonso Y, Kaoma T, Nosirov B, Scafidi A, Ermini L, Lipsa A, Kyriakis D, Grzyb K, Poovathingal SK, Poli A, Muller A,  Toth R, Oudin A,  Klink B,  Berchem G, Berthold C, Hertel F,  Mittelbronn M,  Heiland DH,  Skupin A,  Nazarov PV,  Niclou SP,  Michelucci A,  Golebiewska A;  Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts; Genome Medicine 2024. | Link

Patient avatar collection

  1. Our preclinical models are available to the scientific community via the Patient Derived Models of Cancer Program.
  2. Our collection is part of the EurOPDX consortium.

Additional key publications that relied on the PRECISION-PDX study

Please visit the NORLUX web page to consult the publications.