Services » Luxembourg Institute of Health

LIH-NORLUX BRAIN TUMOUR PATIENT AVATARS

Preclinical services for advancing cancer treatment for patients with brain tumours.

OUR SERVICES

CLINICAL SAMPLES FOR RESEARCH STUDIES (>1200 tumours)

  • Frozen tumour tissue fragments and paraffin blocks
  • Blood derivatives: plasma, serum, buffy coat, PBMCs
  • Clinical parameters and associated diagnostics (histopathological characterization, MRI images, treatment history)

PRECLINICAL MODELS

  • Live biobank of 600 primary organoid models of brain tumours
  • Live biobank of >45 well-characterised glioma patient-derived orthotopic xenograft and primary organoid models with associated molecular characterisation
  • A panel of glioma stem-like cultures and adherent cell lines with associated molecular characterisation

OUR APPLICATIONS

  • Target and biomarker identification in brain tumour tissue or in preclinical models (immunohistochemistry, molecular biology)
  • Treatment efficacy studies:
    • a. In vivo: therapeutic efficacy assessment in PDOXs derived in immunodeficient mice can be combined with MRI-based imaging, survival studies, co-treatment and/or neurosurgery in mice.
    • b. Ex vivo: therapeutic efficacy assessment in PDOX-derived organoids or brain tissue slices can be combined with diverse functional and molecular readouts.
    • c. In vitro: therapeutic efficacy assessment and functional studies in stem-like cultures and adherent cell lines can be combined with diverse functional and molecular readouts.
  • Immunotherapies: Our preclinical models can be applied in advanced set up incorporating human immune compartment i.e., in vivo in humanised mice or in vitro/ex vivo in co-culture systems.

AVAILABLE EQUIPMENT AND FACILITIES