🇬🇧 Mitochondria at the hub of cell death and immunity in irradiated cancer cells
- Lecture Series Cancer Research
Speakers
Galluzzi
Associate Professor, Fox Chase Cancer Center (Philadelphia, PA, US), Honorary Assistant Professor Adjunct, Yale School of Medicine (New Haven, CT, US), Faculty, University of Ferrara Graduate School
(Ferrara, IT), Faculty, University of Padova Graduate School (Padova, IT), Faculty, University of Roma “La Sapienza” Graduate School (Roma, IT), Associate Director, European Academy for Tumor Immunology
Abstract
Immunogenic cell death (ICD) is a functionally defined form of regulated cell death that culminates in the initiation of adaptive immune responses with an active effector phase. Radiation therapy (RT) is a bona fide ICD inducer, as
demonstrated preclinically in both prophylactic vaccination assays and in abscopal tumor models. The ability of RT to drive ICD critically impinges on
type I interferon (IFN) secretion by irradiated cancer cells. We demonstrated that ICD elicited by RT in preclinical models of HR+ breast cancer requires mitochondrial outer membrane permeabilization (MOMP) and is tonically
inhibited by mitophagy and caspases.
Responsible Scientist
Janji
*Please note that registration is mandatory by sending an email to siu-thinh.ho@lih.lu
LOCATION
CHL – Amphitheatre
4, rue Ernest Barblé
L-1210 Luxembourg
LECTURE: 11:00am – 12:00pm
Webinar via Webex:
Event number: 2730 245 7720
Event password: HcZPMyZ9m92
MEET & EAT
12:30pm – 13:30pm
Room: MSA-E03-0352030
Light lunch provided – Registration mandatory*
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