Services » Luxembourg Institute of Health

LIH-NORLUX BRAIN TUMOUR PATIENT AVATARS

Preclinical services for advancing cancer treatment for patients with brain tumours.

Bitte beachten Sie, dass der Inhalt nur auf Englisch verfügbar ist.

OUR SERVICES

CLINICAL SAMPLES FOR RESEARCH STUDIES (>1200 tumours)

  • Frozen tumour tissue fragments and paraffin blocks
  • Blood derivatives: plasma, serum, buffy coat, PBMCs
  • Clinical parameters and associated diagnostics (histopathological characterization, MRI images, treatment history)

PRECLINICAL MODELS

  • Live biobank of 600 primary organoid models of brain tumours
  • Live biobank of >45 well-characterised glioma patient-derived orthotopic xenograft and primary organoid models with associated molecular characterisation
  • A panel of glioma stem-like cultures and adherent cell lines with associated molecular characterisation

OUR APPLICATIONS

  • Target and biomarker identification in brain tumour tissue or in preclinical models (immunohistochemistry, molecular biology)
  • Treatment efficacy studies:
    • a. In vivo: therapeutic efficacy assessment in PDOXs derived in immunodeficient mice can be combined with MRI-based imaging, survival studies, co-treatment and/or neurosurgery in mice.
    • b. Ex vivo: therapeutic efficacy assessment in PDOX-derived organoids or brain tissue slices can be combined with diverse functional and molecular readouts.
    • c. In vitro: therapeutic efficacy assessment and functional studies in stem-like cultures and adherent cell lines can be combined with diverse functional and molecular readouts.
  • Immunotherapies: Our preclinical models can be applied in advanced set up incorporating human immune compartment i.e., in vivo in humanised mice or in vitro/ex vivo in co-culture systems.

AVAILABLE EQUIPMENT AND FACILITIES