🇬🇧 Metabolic requirement of regulatory B cells and plasma cells in health and disease » Luxembourg Institute of Health
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🇬🇧 Metabolic requirement of regulatory B cells and plasma cells in health and disease

17/05/2023 11:00 Ă  14:00
  • Lecture Series Infection & Immunity

Speaker

Prof Claudia
Mauri

Abstract

Regulatory B cells (Bregs) are an immunosuppressive subset of B cells that restore homeostasis following inflammatory responses, primarily via the provision of IL-10.

Bregs have been shown to be numerically and functionally decreased in autoimmunity whilst enriched in primary solid tumors. While the field of immunometabolism is rapidly expanding little is understood about Breg
metabolic requirements. Understanding the metabolic requirement of Bregs over other B cells subsets which may shed light on the dysregulation of this cell subset in disease and provide novel therapeutic targets.

I will present an historical view of Bregs function, and the signals required for their differentiation. I will also share more recent data characterising how Bregs meet their metabolic demands in response to inflammation and how
this can be manipulated for the restoration of B cell responses in patients with SLE.


Responsible Scientist
Dirk
Brenner

LOCATION

House of BioHealth
Conference Room (ground floor 0)
29, rue Henri Koch
L-4354 Esch-sur-Alzette

LECTURE: 11:00am – 12:15pm

Please note that registration is mandatory by sending an email to carole.weis@lih.lu or michelle.roderes@lih.lu

MEET & EAT

12:45pm – 14:00pm light lunch provided

House of BioHealth
Salle Françoise Barré Sinoussi
29 rue Henri Koch
L-4354 Esch-sur-Alzette

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